| Microparticle-associated tissue factor activity and venous thrombosis in multiple myeloma. | |
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MedLine Citation:
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PMID: 21057704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiple myeloma (MM) is associated with an increased risk of venous thromboembolic (VTE) complications. Aim of this study was to measure microparticle-associated tissue factor (MP-TF) activity in patients with newly diagnosed MM before and after chemotherapy and to investigate whether MP-TF activity is associated with VTE. MP-TF activity was assessed in 122 newly diagnosed MM patients who were eligible for combination chemotherapy. MP-TF activity levels (17.6 fM Xa/min [8.6-33.2] (median [IQR]) were higher in untreated MM patients compared to normal healthy volunteers (4.1 fM Xa/min [2.3-6.6], p <0.001). MP-TF activity prior to the start of treatment was not different between patients who developed a VTE during follow-up (n=15) and those who did not (n=107). In 75 patients in whom plasma was obtained before and after chemotherapy, MP-TF activity decreased significantly (from 17.4 [10.2-32.8] to 12.0 [7.0-18.5] fM Xa/min, P=0.006). MP-TF activity remained, however, elevated in patients who developed VTE (15.1 [10.3-25.2]), in contrast to patients not developing VTE (11.4 [7.0-25.2], P<0.001). In conclusion, MP-TF activity is increased in patients with MM. Whether MP-TF activity has a pathogenetic role in VTE in MM patients remains to be established in future studies. |
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Authors:
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Johannes J A Auwerda; Yuana Yuana; Susanne Osanto; Moniek P M de Maat; Pieter Sonneveld; Rogier M Bertina; Frank W G Leebeek |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-11-05 |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 105 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-04 Completed Date: 2011-05-18 Revised Date: 2011-05-23 |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: Germany |
Other Details:
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Languages: eng Pagination: 14-20 Citation Subset: IM |
Affiliation:
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Erasmus University Medical Center, Department of Hematology, Rotterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Boronic Acids / therapeutic use Case-Control Studies Cell-Derived Microparticles / chemistry* Dexamethasone / therapeutic use Doxorubicin / therapeutic use Female Humans Male Middle Aged Multiple Myeloma / chemistry, complications* Pyrazines / therapeutic use Thalidomide / therapeutic use Thromboplastin / analysis, metabolism* Venous Thrombosis / etiology* Vincristine / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Boronic Acids; 0/Pyrazines; 0/bortezomib; 23214-92-8/Doxorubicin; 50-02-2/Dexamethasone; 50-35-1/Thalidomide; 57-22-7/Vincristine; 9035-58-9/Thromboplastin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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