| Micronutrients versus standard medication management in autism: a naturalistic case-control study. | |
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MedLine Citation:
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PMID: 20415604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Autism spectrum disorder (ASD) is often accompanied by self-injurious behavior (SIB), aggression, and tantrums, symptoms that have reportedly improved with micronutrient (vitamins and minerals) treatment. The current study took advantage of naturally occurring differences in parental preferences for treatment approaches. The micronutrient group asked for treatment without pharmaceuticals (n = 44, aged 2-28 years at entry [M = 8.39 +/- 5.58]). Their records were matched with those of 44 similar children whose families requested conventional treatment (medication group). Both groups improved on both the Childhood Autism Rating Scale and the Childhood Psychiatric Rating Scale (all p values <0.0001). Both groups also exhibited significant decreases in total Aberrant Behavior Checklist scores, but the micronutrient group's improvement was significantly greater (p < 0.0001). SIB Intensity was lower in the micronutrient group at the end of the study (p = 0.005), and improvement on the Clinical Global Impressions scale was greater for the micronutrient group (p = 0.0029). It is difficult to determine whether the observed changes were exerted through improvement in mood disorder or through an independent effect on autistic disorder. There were some advantages to treatment with micronutrients-lower activity level, less social withdrawal, less anger, better spontaneity with the examiner, less irritability, lower intensity SIB, markedly fewer adverse events, and less weight gain. Advantages of medication management were insurance coverage, fewer pills, and less frequent dosing. |
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Authors:
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Lewis Mehl-Madrona; Brenda Leung; Carla Kennedy; Sarah Paul; Bonnie J Kaplan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of child and adolescent psychopharmacology Volume: 20 ISSN: 1557-8992 ISO Abbreviation: J Child Adolesc Psychopharmacol Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-07-15 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 9105358 Medline TA: J Child Adolesc Psychopharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 95-103 Citation Subset: IM |
Affiliation:
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Department of Psychology, Argosy University, Honolulu, Hawaii, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Autistic Disorder / complications, drug therapy* Case-Control Studies Child Child, Preschool Female Fish Oils / therapeutic use Humans Male Micronutrients / adverse effects, therapeutic use* Psychotropic Drugs / adverse effects, therapeutic use* Self-Injurious Behavior / complications, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Fish Oils; 0/Micronutrients; 0/Psychotropic Drugs |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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