Document Detail

Micronutrients and their supplementation in chronic cardiac failure. An update beyond theoretical perspectives.
MedLine Citation:
PMID:  16819579     Owner:  NLM     Status:  MEDLINE    
Physicians' use of micronutrients to improve symptoms or outcomes in chronic illness has until recently been guided by limited data on the actions of individual agents in vitro or in animal studies. However several recently published clinical trials have provided information about which groups of patients are likely to benefit from which combination of micronutrients. Patients with chronic cardiac failure (CCF), particularly elderly individuals, have several reasons to be deficient in micronutrients including reduced intake, impaired gastrointestinal absorption and increased losses on the background of increased utilisation due for example to increased oxidative stress. Studies of nutritional supplementation in CCF patients have usually concentrated on specific agents. However given that many micronutrients have synergistic influences upon metabolic processes this strategy might merely lead to a shifting of a limiting step. Rather, a strategy of increasing the availability of multiple agents at once might be more logical. The aim of this article is to briefly review the experimental rationale for each of the micronutrients of potential benefit in chronic heart failure and examine the current clinical trial evidence supporting their use.
Klaus K Witte; Andrew L Clark
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Heart failure reviews     Volume:  11     ISSN:  1382-4147     ISO Abbreviation:  Heart Fail Rev     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-07-05     Completed Date:  2006-11-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9612481     Medline TA:  Heart Fail Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  65-74     Citation Subset:  IM    
Mount Sinai Hospital, University Health Network, 600 University Avenue, Toronto, ON, M5J 1X5, Canada.
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MeSH Terms
Antioxidants / therapeutic use
Ascorbic Acid / metabolism
Calcium / physiology
Carnitine / therapeutic use
Copper / metabolism
Dietary Supplements*
Heart Failure / drug therapy*,  metabolism,  physiopathology*
Magnesium / metabolism
Magnesium Deficiency / metabolism
Micronutrients / metabolism,  physiology*,  therapeutic use*
Niacin / deficiency,  metabolism
Oxidative Stress / physiology
Phosphocreatine / metabolism,  therapeutic use
Ubiquinone / therapeutic use
Vitamin B Complex / metabolism
Vitamin B Deficiency / metabolism,  physiopathology
Vitamin E / metabolism,  therapeutic use
Zinc / metabolism
Reg. No./Substance:
0/Antioxidants; 0/Micronutrients; 12001-76-2/Vitamin B Complex; 1339-63-5/Ubiquinone; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 541-15-1/Carnitine; 59-67-6/Niacin; 67-07-2/Phosphocreatine; 7439-95-4/Magnesium; 7440-50-8/Copper; 7440-66-6/Zinc; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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