| Micronutrients in the severely-injured patient. | |
| | |
MedLine Citation:
|
PMID: 10997673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The trace element and vitamin requirements of severely-ill injured patients depend on a complex interaction of the status of the patient at the time of admission, ongoing losses and the potential benefit of supplying large amounts of individual micronutrients. Characteristic clinical deficiency states are now uncommon, but subclinical deficiency is of growing concern. The main effects of subclinical deficiency are: (1) an altered balance of reactive oxygen species and antioxidants, leading to oxidative damage of polyunsaturated fatty acids and nucleic acids, and possibly to increased activation of the transcription factor nuclear factor-kappaB, with increased production of pro-inflammatory cytokines: (2) impaired immune function with increased likelihood of infectious complications. Laboratory tests to optimize intake in such critically-ill patients lack sensitivity and specificity, this situation being made worse as a result of the acute-phase response. Recent studies have indicated the clinical benefit of providing large amounts of certain micronutrients in burned and head-injured patients. Further clinical studies are now required to define optimal levels of provision in different disease states, with a particular emphasis on markers of tissue function and clinical outcome. |
| | |
Authors:
|
A Shenkin |
Related Documents
:
|
8380553 - Impaired beta-adrenergic receptor stimulation of cyclic adenosine monophosphate in huma... 1930673 - Pyogenic pericarditis in a patient with burns--a rare complication. 20584223 - The association between serum uric acid level and coronary artery disease. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: The Proceedings of the Nutrition Society Volume: 59 ISSN: 0029-6651 ISO Abbreviation: Proc Nutr Soc Publication Date: 2000 Aug |
Date Detail:
|
Created Date: 2000-12-06 Completed Date: 2001-03-01 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 7505881 Medline TA: Proc Nutr Soc Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 451-6 Citation Subset: IM |
Affiliation:
|
Department of Clinical Chemistry, University of Liverpool, UK. shenkin@liverpool.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Avitaminosis
/
diet therapy,
metabolism Basal Metabolism Humans Micronutrients / deficiency, metabolism* Nutrition Assessment Nutritional Requirements Nutritional Status* Oxidation-Reduction Trace Elements / adverse effects, deficiency* Vitamins / administration & dosage Wounds and Injuries / diet therapy, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Micronutrients; 0/Trace Elements; 0/Vitamins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Substrate metabolism in the metabolic response to injury.
Next Document: Parenteral nutrition in the critically-ill patient: more harm than good?