| Micronutrients at the interface between inflammation and infection--ascorbic acid and calciferol: part 1, general overview with a focus on ascorbic acid. | |
| | |
MedLine Citation:
|
PMID: 21184650 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
As elements of the antioxidant system, cofactors of enzymes, components of transcription factors, and epigenetic modulators, micronutrients, such as vitamins and trace elements, influence various metabolic processes that are directly associated with immune functions. Specifically, the vitamins C and D have been shown to have significance immune function. Therefore, the objective of this review is to elucidate interactions between micronutrients and the immune system. In the initial section of this review, we present a general overview of interactions between the immune system and micronutrients, with a focus on the immunobiologically relevant functions of vitamin C. Immune competent cells accumulate vitamin C against a concentration gradient, with a close relationship between vitamin C supply and immune cell activity, especially phagocytosis activity and T-cell function. Accordingly, one of the consequences of vitamin C deficiency is impaired resistance to various pathogens, while an enhanced supply increases antibody activity and infection resistance. |
| | |
Authors:
|
Alexander Ströhle; Maike Wolters; Andreas Hahn |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Inflammation & allergy drug targets Volume: 10 ISSN: 2212-4055 ISO Abbreviation: Inflamm Allergy Drug Targets Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-21 Completed Date: 2011-05-09 Revised Date: 2011-11-10 |
Medline Journal Info:
|
Nlm Unique ID: 101266886 Medline TA: Inflamm Allergy Drug Targets Country: United Arab Emirates |
Other Details:
|
Languages: eng Pagination: 54-63 Citation Subset: IM |
Affiliation:
|
Institute of Food Science and Human Nutrition, Leibniz University of Hannover, Hannover, Germany. stroehle@nutrition.uni-hannover.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Ascorbic Acid / metabolism*, therapeutic use Ascorbic Acid Deficiency / drug therapy, immunology, metabolism Communicable Diseases / immunology, metabolism* Dietary Supplements Ergocalciferols / metabolism Humans Immune System / metabolism* Inflammation / immunology, metabolism*, prevention & control Inflammation Mediators / metabolism Signal Transduction |
| Chemical | |
Reg. No./Substance:
|
0/Ergocalciferols; 0/Inflammation Mediators; 50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Up-regulation of Gr1+CD11b+ population in spleen of dextran sulfate sodium administered mice works t...
Next Document: Polycations selectively blocking tissue factor-dependent FVII activation: collective in vitro antico...