Document Detail

Micronutrients, birth weight, and survival.
MedLine Citation:
PMID:  20415580     Owner:  NLM     Status:  MEDLINE    
Maternal micronutrient requirements during pregnancy increase to meet the physiologic changes in gestation and fetal demands for growth and development. Maternal micronutrient deficiencies are high and coexist in many settings, likely influencing birth and newborn outcomes. The only recommendation for pregnancy currently exists for iron and folic acid use. Evidence is convincing that maternal iron supplementation will improve birth weight and perhaps gestational length. In one randomized trial, iron supplementation during pregnancy reduced child mortality in the offspring compared with the control group. Few other single micronutrients given antenatally, including vitamin A, zinc, and folic acid, have been systematically shown to confer such a benefit. A meta-analysis of 12 trials of multiple micronutrient supplementation compared with iron-folic acid reveals an overall 11% reduction in low birth weight but no effect on preterm birth and perinatal or neonatal survival. Currently, data are unconvincing for replacing supplementation of antenatal iron-folic acid with multiple micronutrients.
Parul Christian
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annual review of nutrition     Volume:  30     ISSN:  1545-4312     ISO Abbreviation:  Annu. Rev. Nutr.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8209988     Medline TA:  Annu Rev Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  83-104     Citation Subset:  IM    
Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
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MeSH Terms
Birth Weight* / drug effects,  physiology
Dietary Supplements
Infant Mortality
Infant, Newborn
Maternal Nutritional Physiological Phenomena / physiology*
Micronutrients / administration & dosage*,  physiology*
Nutritional Requirements
Pregnancy Outcome
Prenatal Nutritional Physiological Phenomena / physiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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