| Micronutrient prenatal supplementation prevents the development of hypertension and vascular endothelial damage induced by intrauterine malnutrition. | |
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MedLine Citation:
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PMID: 19576906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The premise that intrauterine malnutrition plays an important role in the development of cardiovascular and renal diseases implies that these disorders can be programmed during fetal life. Here, we analyzed the hypothesis that supplementation with mixed antioxidant vitamins and essential mineral in early life could prevent later elevation of blood pressure and vascular and renal dysfunction associated with intrauterine malnutrition. MAIN METHODS: For this, female Wistar rats were randomly divided into three groups on day 1 of pregnancy: control fed standard chow ad libitum; restricted group fed 50% of the ad libitum intake and a restricted plus micronutrient cocktail group treated daily with a combination of micronutrient (selenium, folate, vitamin C and vitamin E) by oral gavage. KEY FINDINGS: In adult offspring, renal function and glomerular number were impaired by intrauterine malnutrition, and the prenatal micronutrient treatment did not prevent it. However, increased blood pressure and reduced endothelium-dependent vasodilation were prevented by the micronutrient prenatal treatment. Intrauterine malnutrition also led to reduced NO production associated with increased superoxide generation, and these parameters were fully normalized by this prenatal treatment. SIGNIFICANCE: Our current findings indicate that programming alterations during fetal life can be prevented by interventions during the prenatal period, and that disturbance in availability of both antioxidant vitamins and mineral may play a crucial role in determining the occurrence of long-term cardiovascular injury. |
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Authors:
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Maria do Carmo Franco; Beatriz Felice Ponzio; Guiomar Nascimento Gomes; Frida Zaladek Gil; Rita Tostes; Maria Helena Catelli Carvalho; Zuleica Bruno Fortes |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-02 |
Journal Detail:
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Title: Life sciences Volume: 85 ISSN: 1879-0631 ISO Abbreviation: Life Sci. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-03 Completed Date: 2009-08-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 327-33 Citation Subset: IM |
Affiliation:
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Federal University of São Paulo - Nephrology Division - Medicine Department, R. Botucatu, 740 - São Paulo, SP 04023-900, Brazil. mdcfranco@nefro.epm.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Thoracic / drug effects, growth & development Blood Pressure / drug effects Dietary Supplements* Endothelium, Vascular / drug effects, pathology* Female Fetal Nutrition Disorders / prevention & control* Hypertension / pathology, prevention & control* Kidney / drug effects, growth & development Kidney Function Tests Micronutrients / administration & dosage, therapeutic use* Nitric Oxide / metabolism Pregnancy Prenatal Exposure Delayed Effects / pathology, prevention & control* Rats Superoxides / metabolism Vasodilation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Micronutrients; 10102-43-9/Nitric Oxide; 11062-77-4/Superoxides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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