| Micronucleus analysis in patients with colorectal adenocarcinoma and colorectal polyps. | |
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MedLine Citation:
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PMID: 19058310 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To determine, by counting micronucleus (MN) frequencies, whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC). METHODS: We analyzed MN frequencies in 21 patients with CRC, 24 patients with colon polyps [10 neoplastic polyps (NP) and 14 non-neoplastic polyps (NNP)] and 20 normal controls. RESULTS: MN frequency was significantly increased in CRC patients and in NP patients compared with controls (3.72 +/- 1.34, 3.58 +/- 1.21 vs 1.97 +/- 0.81, P < 0.001). However, there was no difference in the MN frequency between CRC patients and NP patients (P > 0.05). Similarly, there was no difference in the MN frequency between NNP patients (2.06 +/- 0.85) and controls (P > 0.05). CONCLUSION: Our results suggest increased chromosome/DNA instabilities may be associated with the pathogenesis of early CRC. |
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Authors:
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Ali Karaman; Doğan Nasir Binici; Mehmet Eşref Kabalar; Züleyha Calikuşu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 14 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-12-05 Completed Date: 2009-04-09 Revised Date: 2010-09-23 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 6835-9 Citation Subset: IM |
Affiliation:
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Erzurum Training and Research Hospital, Department of Medical Genetics, Erzurum 25240, Turkey. alikaramandr@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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genetics*,
pathology Aged Case-Control Studies Cell Transformation, Neoplastic / genetics Cells, Cultured Colonic Polyps / genetics*, pathology Colonoscopy Colorectal Neoplasms / genetics*, pathology Female Gene Expression Regulation, Neoplastic Genomic Instability* Humans Male Micronuclei, Chromosome-Defective* Micronucleus Tests Middle Aged Precancerous Conditions / genetics*, pathology |
| Comments/Corrections | |
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