| Micronuclei frequencies in peripheral blood and buccal exfoliated cells of young smokers and non-smokers. | |
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MedLine Citation:
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PMID: 20450262 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cytogenetic biomarkers, such as micronuclei in peripheral blood or oral mucosa, are widely used for evaluation of exposure to genotoxins or carcinogens. Tobacco is one of the strongest carcinogens, responsible for development of different types of cancers. The aim of this study was to assess the genotoxicity of cigarette consumption in young smokers and to correlate results of cytogenetic analysis in peripheral blood lymphocytes and exfoliated buccal cells. The study was conducted on samples taken from 43 smokers and 44 non-smokers, young individuals from Bosnia and Herzegovina. Significantly higher frequency of micronuclei in peripheral blood lymphocytes was observed in smokers (p < 0.05). No significant correlations were found for age, duration and intensity of smoking, and frequency of micronuclei in lymphocytes. Significantly higher frequency of degenerated (apoptotic) buccal cells was also revealed in smokers (p < 0.05). The frequency of apoptotic cells in smokers was significantly influenced by the age of participants (F = 8.649; p < 0.01) and duration of smoking (F = 5.389; p < 0.05). Results of cytogenetic analysis conducted in peripheral blood and exfoliated buccal cells are in significant positive correlation, indicating complementarities of those analyses. |
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Authors:
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Anja Haveric; Sanin Haveric; Slavka Ibrulj |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Toxicology mechanisms and methods Volume: 20 ISSN: 1537-6524 ISO Abbreviation: Toxicol. Mech. Methods Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-20 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101134521 Medline TA: Toxicol Mech Methods Country: England |
Other Details:
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Languages: eng Pagination: 260-6 Citation Subset: IM |
Affiliation:
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Institute for Genetic Engineering and Biotechnology, Sarajevo, Bosnia and Herzegovina. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carcinogens / toxicity* Cheek Cytogenetic Analysis Environmental Exposure / analysis Female Humans Leukocytes, Mononuclear / drug effects Male Micronuclei, Chromosome-Defective* Micronucleus Tests Mouth Mucosa / drug effects*, ultrastructure Mutagens / toxicity* Smoking / adverse effects* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Mutagens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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