| Micronucleated erythrocytes in preterm newborns exposed to phototherapy and/or oxygentherapy. | |
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MedLine Citation:
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PMID: 22209030 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Preterm newborns (PNBs) have an immature antioxidant defense system, and this makes them more susceptible to oxidative stress generated by postnatal treatments. The objective was to determine whether micronucleated erythrocytes increase in PNB by postnatal treatments such as oxygentherapy and phototherapy. We counted micronucleated erythrocytes and micronucleated polychromatic erythrocytes as DNA damage in 72 blood samples of PNB at 26-36weeks of gestation, taken between 1 and 84h after birth. We assume that more time passed between sampling and birth would correspond to greater time of exposure to oxygen (37 cases) and phototherapy plus oxygen (35 cases). In the PNB only exposed to oxygen, the differences were not significant, while there was a significant increase in micronucleated polychromatic erythrocytes with increasing exposure time in those treated with phototherapy plus oxygen. In conclusion, our results suggest that the MN increase from phototherapy can be observed in peripheral blood erythrocytes of PNB. |
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Authors:
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Guillermo M Zúñiga-González; Belinda C Gómez-Meda; María de Lourdes Lemus-Varela; Ana L Zamora-Perez; Juan Armendáriz-Borunda; Angélica Barros-Hernández; Adriana Sánchez-Díaz; Martha P Gallegos-Arreola |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-13 |
Journal Detail:
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Title: Journal of photochemistry and photobiology. B, Biology Volume: - ISSN: 1873-2682 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804966 Medline TA: J Photochem Photobiol B Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Laboratorio de Mutagénesis, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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