Document Detail

Micronized flavonoids in pain control after hemorrhoidectomy: a prospective randomized controlled study.
MedLine Citation:
PMID:  14605954     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We conducted a prospective randomized controlled study to evaluate the effect of micronized flavonoid fractions (MFF) on pain after hemorrhoidectomy. METHODS: The subjects were 112 consecutive patients randomly assigned either to receive MFF (group 1) for 1 week or not to receive MFF, as a control (group 2), after hemorrhoidectomy, The severity of pain and the number of intramuscular analgesic injections required were recorded for the first 3 days, then 1 week after hemorrhoidectomy. The number of days that intramuscular analgesic injections were required, hospital stay, and patient satisfaction were also assessed. RESULTS: On postoperative day (POD) 1, there were no significant differences between the parameters of the two groups, but on PODs 2 and 3, both the pain score ( P = 0.033 and P = 0.011, respectively) and the number of patients who required intramuscular analgesic injections were significantly less in group 1 ( P = 0.022 and P = 0.007, respectively). Moreover, the hospital stay was shorter and patient satisfaction was superior in group 1 ( P = 0.001 and P = 0.001, respectively). After 1 week, the pain score and number of intramuscular analgesic injections given were significantly less in group 1 ( P = 0.001 and P = 0.021). CONCLUSION: Using MFF after hemorrhoidectomy reduced the severity of pain and intramuscular analgesic requirement.
Tahsin Colak; Tamer Akca; Musa Dirlik; Arzu Kanik; Ahmet Dag; Suha Aydin
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Surgery today     Volume:  33     ISSN:  0941-1291     ISO Abbreviation:  Surg. Today     Publication Date:  2003  
Date Detail:
Created Date:  2003-11-07     Completed Date:  2004-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  828-32     Citation Subset:  IM    
Department of Surgery, Mersin Medical Faculty of Mersin University, Tip Fakultesi Hastanesi Zeytinlibahce C, 33079 Mersin, Turkey.
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MeSH Terms
Aged, 80 and over
Analgesics / therapeutic use
Dose-Response Relationship, Drug
Drug Administration Schedule
Flavonoids / administration & dosage*
Follow-Up Studies
Hemorrhoids / diagnosis,  surgery*
Middle Aged
Pain Measurement
Pain, Postoperative / drug therapy*,  prevention & control
Prospective Studies
Reference Values
Severity of Illness Index
Statistics, Nonparametric
Treatment Outcome
Reg. No./Substance:
0/Analgesics; 0/Flavonoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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