Document Detail


Microiontophoretic release of drugs from micropipettes: use of 24Na as a model.
MedLine Citation:
PMID:  4724187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The use of (24)Na(+) of high specific activity allowed its iontophoretic release from multibarrelled glass micropipettes to be followed over short periods with low currents.2. When a negative retaining current was passed to reduce diffusional efflux between the periods of positive current expulsion of (24)Na(+), the rate of release of (24)Na(+) during the expulsion period progressively increased during the first minute before becoming constant.3. The currents employed were similar to those normally used to regulate the microiontophoretic release of potent drugs such as gamma-aminobutyric acid. It is therefore concluded that, during the usual period of response to such drugs, the rate of release of drug is not constant but increasing.4. The implications of these observations for the construction of microiontophoretic dose-response relationships is discussed.
Authors:
G Clarke; R G Hill; M A Simmonds
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  48     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1973 May 
Date Detail:
Created Date:  1973-10-12     Completed Date:  1973-10-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  156-61     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cerebral Cortex / drug effects
Iontophoresis*
Mathematics
Microinjections
Models, Chemical
Rats
Sodium* / metabolism
Sodium Isotopes
Time Factors
Chemical
Reg. No./Substance:
0/Sodium Isotopes; 7440-23-5/Sodium
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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