Document Detail

Microinvasive lentigo maligna melanoma.
MedLine Citation:
PMID:  3312317     Owner:  NLM     Status:  MEDLINE    
Ninety-one skin biopsy specimens previously identified as lentigo maligna were examined for the presence of microinvasion, using the demonstration of S100 protein within atypical cells as the means for locating these superficial foci. In 14 cases, atypical melanocytes were identified, most often in the papillary dermis. The mean depth of invasion in this group was 0.23 mm with a range of 0.10 mm to 0.75 mm. In these cases, atypical cells were difficult if not impossible to identify in routinely processed sections, either because the invasive cell was a spindle cell variant and indistinguishable from a fibrohistiocytic cell, because the invasive cells were occasionally solitary or in small groups, or because there was an inflammatory infiltrate that obscured the tumor cells. Recent studies of lentigo maligna melanoma have revealed no better prognosis when compared to that of other forms of malignant melanoma after normalization for depth and body location. We therefore advocate close examination of lentigo maligna with the use of appropriate immunohistochemical techniques if there are areas of dermal fibrosis or inflammation that might obscure invasion.
N S Penneys
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  17     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-12-15     Completed Date:  1987-12-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  675-80     Citation Subset:  IM    
Department of Dermatology, University of Miami School of Medicine, FL.
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MeSH Terms
Immunoenzyme Techniques
Melanocytes / analysis,  pathology
Melanoma / analysis,  pathology*
Neoplasm Invasiveness
Retrospective Studies
S100 Proteins / analysis
Skin Neoplasms / analysis,  pathology*
Reg. No./Substance:
0/S100 Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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