| Microinvasive lentigo maligna melanoma. | |
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MedLine Citation:
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PMID: 3312317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ninety-one skin biopsy specimens previously identified as lentigo maligna were examined for the presence of microinvasion, using the demonstration of S100 protein within atypical cells as the means for locating these superficial foci. In 14 cases, atypical melanocytes were identified, most often in the papillary dermis. The mean depth of invasion in this group was 0.23 mm with a range of 0.10 mm to 0.75 mm. In these cases, atypical cells were difficult if not impossible to identify in routinely processed sections, either because the invasive cell was a spindle cell variant and indistinguishable from a fibrohistiocytic cell, because the invasive cells were occasionally solitary or in small groups, or because there was an inflammatory infiltrate that obscured the tumor cells. Recent studies of lentigo maligna melanoma have revealed no better prognosis when compared to that of other forms of malignant melanoma after normalization for depth and body location. We therefore advocate close examination of lentigo maligna with the use of appropriate immunohistochemical techniques if there are areas of dermal fibrosis or inflammation that might obscure invasion. |
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Authors:
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N S Penneys |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: 17 ISSN: 0190-9622 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 1987 Oct |
Date Detail:
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Created Date: 1987-12-15 Completed Date: 1987-12-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 675-80 Citation Subset: IM |
Affiliation:
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Department of Dermatology, University of Miami School of Medicine, FL. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Female Humans Immunoenzyme Techniques Male Melanocytes / analysis, pathology Melanoma / analysis, pathology* Neoplasm Invasiveness Retrospective Studies S100 Proteins / analysis Skin Neoplasms / analysis, pathology* |
| Chemical | |
Reg. No./Substance:
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0/S100 Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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