| Microinjection of muscimol into the dorsomedial hypothalamus suppresses MDMA-evoked sympathetic and behavioral responses. | |
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MedLine Citation:
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PMID: 18586013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When given systemically to rats and humans, the drug of abuse 3,4 methylenedioxymethamphetamine (ecstasy, MDMA) elicits hyperthermia, hyperactivity, tachycardia, and hypertension. Chemically stimulating the dorsomedial hypothalamus (DMH), a brain region known to be involved in thermoregulation and in stress responses, causes similar effects. We therefore tested the hypothesis that neuronal activity in the DMH plays a role in MDMA-evoked sympathetic and behavioral responses by microinjecting artificial CSF or muscimol, a neuronal inhibitor, into the DMH prior to intravenous infusion of saline or MDMA in conscious rats. Core temperature, heart rate, mean arterial pressure and locomotor activity were recorded by telemetry every minute for 120 min. In rats previously microinjected with CSF, MDMA elicited significant increases from baseline in core temperature (+1.3+/-0.3 degrees C), locomotion (+50+/-6 counts/min), heart rate (+142+/-16 beats/min), and mean arterial pressure (+26+/-3 mmHg). Microinjecting muscimol into the DMH prior to MDMA prevented increases in core temperature and locomotion and attenuated increases in heart rate and mean arterial pressure. These results indicate that neuronal activity in the DMH is necessary for the sympathetic and behavioral responses evoked by MDMA. |
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Authors:
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Daniel E Rusyniak; Maria V Zaretskaia; Dmitry V Zaretsky; Joseph A DiMicco |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-06-14 |
Journal Detail:
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Title: Brain research Volume: 1226 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-15 Completed Date: 2009-01-07 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 116-23 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202-2859, USA. drusynia@iupui.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic Uptake Inhibitors
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pharmacology* Animals Behavior, Animal / drug effects* Blood Pressure / drug effects Body Temperature / drug effects Dorsomedial Hypothalamic Nucleus / drug effects* Drug Interactions GABA Agonists / pharmacology* Heart Rate / drug effects Locomotion / drug effects Male Microinjections / methods Muscimol / pharmacology* N-Methyl-3,4-methylenedioxyamphetamine / pharmacology* Rats Rats, Sprague-Dawley Sympathetic Nervous System / drug effects*, physiology |
| Grant Support | |
ID/Acronym/Agency:
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C06 RR015481-01/RR/NCRR NIH HHS; DA20484/DA/NIDA NIH HHS; K08 DA020484/DA/NIDA NIH HHS; K08 DA020484-01/DA/NIDA NIH HHS; K08 DA020484-02/DA/NIDA NIH HHS; K08 DA020484-03/DA/NIDA NIH HHS; NS19883/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic Uptake Inhibitors; 0/GABA Agonists; 2763-96-4/Muscimol; 42542-10-9/N-Methyl-3,4-methylenedioxyamphetamine |
| Comments/Corrections | |
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