| Microinflammation in Hemodialysis Patients Is Associated with Increased CD14CD16(+) Pro-Inflammatory Monocytes: Possible Modification by On-Line Hemodiafiltration. | |
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MedLine Citation:
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PMID: 21242682 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: An increased percentage of pro-inflammatory CD14(+)CD16(+) monocytes might contribute to inflammation in hemodialysis (HD) patients. The purpose of the study was to evaluate the possible contribution of pro-inflammatory monocytes to inflammation in HD patients and also to evaluate the effect of on-line hemodiafiltration (HDF). Methods: Flow cytometric detection of monocytes in patients undergoing HD, on-line HDF and healthy controls as well as plasma cytokines and cytokine mRNA measurement were performed. Results: Percent pro-inflammatory monocytes, plasma cytokines and cytokine mRNA significantly increased in HD patients. Intracellular cytokine staining showed pro-inflammatory monocytes were the predominant source of tumor necrosis factor-α. Percent pro-inflammatory monocytes positively correlated with plasma inflammatory cytokines. Percent pro-inflammatory monocytes, plasma cytokines and cytokine mRNA significantly decreased in on-line HDF patients. Conclusion: Increased pro-inflammatory monocytes are likely to contribute to inflammation in HD patients, and beneficial effect of on-line HDF might be partially mediated by modulating the inflammatory response. |
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Authors:
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Hye Won Kim; Ha-Na Yang; Myung Gyu Kim; Hye Min Choi; Sang-Kyung Jo; Won Yong Cho; Hyoung Kyu Kim |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-13 |
Journal Detail:
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Title: Blood purification Volume: 31 ISSN: 1421-9735 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8402040 Medline TA: Blood Purif Country: - |
Other Details:
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Languages: ENG Pagination: 281-288 Citation Subset: - |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Division of Nephrology, Department of Internal Medicine, Korea University Medical College, Seoul, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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