Document Detail


Microheterogeneity of regional myocardial blood flows in low-perfused rat hearts evaluated by double-tracer digital radiography.
MedLine Citation:
PMID:  17574429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using (3)H- and (125)I-labeled desmethylimipramine (DMI) for regional flow tracers, we established a two-time measurement method for the spatial pattern of myocardial perfusion in cross-circulated rat hearts. Myocardial extractions and retentions of these tracers were confirmed to be satisfactory; however, the latter were less than 90% after 3 min at a perfusion rate of 2.9 ml/min/g, limiting the present application to a short-time perfusion measurement. Distributions of myocardial depositions were separated by subtraction digital radiography with 400-microm pixel resolution. Its feasibility was examined by regression analysis between local deposition densities of (3)H- and (125)I-DMI injected simultaneously. The slope, y-intercept, and correlation coefficient (r) of the regression line were 0.98+/-0.04, 0.02+/-0.04, and 0.95+/-0.03, respectively, indicating the validity of the present image subtraction technique. The spatial pattern of myocardial perfusion in response to flow reduction was evaluated by the injections of (3)H- and (125)I-DMI, respectively, before and after a nearly 70% flow reduction. A significant correlation between normalized density distributions of these tracers was found in both subepicardium (r=0.77+/-0.12) and subendocardium (r=0.73+/-0.20), indicating the stable pattern of myocardial perfusion. However, the coefficient of variation of tracer densities showed a decrease of subendocardial flow heterogeneity from 35+/-15% to 31+/-16%. Thus, flow differences between originally high- and low-flow regions in subendocardium were reduced on a relative basis during low perfusion.
Authors:
Takeshi Matsumoto; Takahisa Asano; Mami Takemoto; Hiroyuki Tachibana; Yasuo Ogasawara; Fumihiko Kajiya
Related Documents :
12433979 - Spatial heterogeneity in the heart: recent insights and open questions.
8854839 - Long-term cigarette smoking is associated with increased myocardial perfusion heterogen...
18287669 - The isolated, perfused pseudo-working heart model.
14611829 - Assessment of regional myocardial hypoperfusion with myocardial contrast echocardiograp...
4074839 - Quantitative 31p nuclear magnetic resonance analysis of metabolite concentrations in la...
21730309 - Development and validation of a risk calculator for prediction of cardiac risk after su...
2122259 - Modification by glibenclamide of the electrophysiological consequences of myocardial is...
12436749 - History of cardiac physiology in the framework of the german society for circulation re...
14739749 - Loss of left bundle branch block following biventricular pacing therapy for heart failu...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-23
Journal Detail:
Title:  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine     Volume:  65     ISSN:  0969-8043     ISO Abbreviation:  Appl Radiat Isot     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-16     Completed Date:  2007-10-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306253     Medline TA:  Appl Radiat Isot     Country:  England    
Other Details:
Languages:  eng     Pagination:  910-7     Citation Subset:  IM    
Affiliation:
Bioengineering Division, Osaka University Graduate School of Engineering Science, Machikaneyamacho 13, Toyonaka 5608531, Japan. matsu@me.es.osaka-u.ac.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Autoradiography / methods*
Coronary Circulation / physiology*
Desipramine / diagnostic use*
Deuterium / diagnostic use
Iodine Radioisotopes / diagnostic use*
Perfusion / methods
Radiographic Image Enhancement / methods*
Rats
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes; 50-47-5/Desipramine; 7782-39-0/Deuterium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  High-resolution measurements of small field beams using polymer gels.
Next Document:  A novel approach to restore atrial function after the maze procedure in patients with an enlarged le...