| Microheterogeneity of regional myocardial blood flows in low-perfused rat hearts evaluated by double-tracer digital radiography. | |
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MedLine Citation:
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PMID: 17574429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using (3)H- and (125)I-labeled desmethylimipramine (DMI) for regional flow tracers, we established a two-time measurement method for the spatial pattern of myocardial perfusion in cross-circulated rat hearts. Myocardial extractions and retentions of these tracers were confirmed to be satisfactory; however, the latter were less than 90% after 3 min at a perfusion rate of 2.9 ml/min/g, limiting the present application to a short-time perfusion measurement. Distributions of myocardial depositions were separated by subtraction digital radiography with 400-microm pixel resolution. Its feasibility was examined by regression analysis between local deposition densities of (3)H- and (125)I-DMI injected simultaneously. The slope, y-intercept, and correlation coefficient (r) of the regression line were 0.98+/-0.04, 0.02+/-0.04, and 0.95+/-0.03, respectively, indicating the validity of the present image subtraction technique. The spatial pattern of myocardial perfusion in response to flow reduction was evaluated by the injections of (3)H- and (125)I-DMI, respectively, before and after a nearly 70% flow reduction. A significant correlation between normalized density distributions of these tracers was found in both subepicardium (r=0.77+/-0.12) and subendocardium (r=0.73+/-0.20), indicating the stable pattern of myocardial perfusion. However, the coefficient of variation of tracer densities showed a decrease of subendocardial flow heterogeneity from 35+/-15% to 31+/-16%. Thus, flow differences between originally high- and low-flow regions in subendocardium were reduced on a relative basis during low perfusion. |
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Authors:
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Takeshi Matsumoto; Takahisa Asano; Mami Takemoto; Hiroyuki Tachibana; Yasuo Ogasawara; Fumihiko Kajiya |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-23 |
Journal Detail:
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Title: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine Volume: 65 ISSN: 0969-8043 ISO Abbreviation: Appl Radiat Isot Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-16 Completed Date: 2007-10-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9306253 Medline TA: Appl Radiat Isot Country: England |
Other Details:
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Languages: eng Pagination: 910-7 Citation Subset: IM |
Affiliation:
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Bioengineering Division, Osaka University Graduate School of Engineering Science, Machikaneyamacho 13, Toyonaka 5608531, Japan. matsu@me.es.osaka-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoradiography / methods* Coronary Circulation / physiology* Desipramine / diagnostic use* Deuterium / diagnostic use Iodine Radioisotopes / diagnostic use* Perfusion / methods Radiographic Image Enhancement / methods* Rats Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes; 50-47-5/Desipramine; 7782-39-0/Deuterium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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