Document Detail


Microgranular acute promyelocytic leukemia: a proposed role for a greater deformability of the leukemic cell.
MedLine Citation:
PMID:  2915920     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A case of microgranular acute promyelocytic leukemia (APL), M-3 variant, is reported in a boy aged 5 years. The disease, which was rapidly fatal, presented with acute disseminated intravascular coagulation (DIC) and leukocytosis. Different cytomorphologic subtypes of promyelocytes were identified on the basis of cytoplasmic granular patterns: the microgranular type with barely visible cytoplasmic granulations and deeply basophilic cytoplasm and the more characteristic type with large promyelocytes containing azurophil granules. We observed a ratio of large promyelocytes to microgranular promyelocytes of 1:1.2 in the marrow and 1:4 in the peripheral blood. To explain this discrepancy, we hypothesize that the microgranular promyelocytes may be more deformable than the typical promyelocyte and that this intrinsic cellular characteristic may promote marrow egress and increase the likelihood of hyperleukocytosis in the M-3 variant.
Authors:
G Cantin; V Bernier; S Jacob; J Lyonnais
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Nouvelle revue française d'hématologie     Volume:  31     ISSN:  -     ISO Abbreviation:  Nouv Rev Fr Hematol     Publication Date:  1989  
Date Detail:
Created Date:  1989-03-23     Completed Date:  1989-03-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909092     Medline TA:  Nouv Rev Fr Hematol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  23-6     Citation Subset:  IM    
Affiliation:
Centre d'Hématologie et d'Immunologie Clinique, Hôpital du Saint-Sacrement, Laval, Québec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Bone Marrow / pathology
Cell Membrane / pathology*
Cell Transformation, Neoplastic / pathology*,  ultrastructure
Child, Preschool
Cytoplasmic Granules / pathology*,  ultrastructure
Humans
Karyotyping
Leukemia, Promyelocytic, Acute / blood,  genetics,  pathology*
Male

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