Document Detail


Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner.
MedLine Citation:
PMID:  22632727     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microglia are the resident CNS immune cells and active surveyors of the extracellular environment. While past work has focused on the role of these cells during disease, recent imaging studies reveal dynamic interactions between microglia and synaptic elements in the healthy brain. Despite these intriguing observations, the precise function of microglia at remodeling synapses and the mechanisms that underlie microglia-synapse interactions remain elusive. In the current study, we demonstrate a role for microglia in activity-dependent synaptic pruning in the postnatal retinogeniculate system. We show that microglia engulf presynaptic inputs during peak retinogeniculate pruning and that engulfment is dependent upon neural activity and the microglia-specific phagocytic signaling pathway, complement receptor 3(CR3)/C3. Furthermore, disrupting microglia-specific CR3/C3 signaling resulted in sustained deficits in synaptic connectivity. These results define a role for microglia during postnatal development and identify underlying mechanisms by which microglia engulf and remodel developing synapses.
Authors:
Dorothy P Schafer; Emily K Lehrman; Amanda G Kautzman; Ryuta Koyama; Alan R Mardinly; Ryo Yamasaki; Richard M Ransohoff; Michael E Greenberg; Ben A Barres; Beth Stevens
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuron     Volume:  74     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-28     Completed Date:  2012-08-03     Revised Date:  2014-03-20    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  691-705     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / physiology*
Macrophage-1 Antigen / genetics,  metabolism*
Mice
Mice, Knockout
Microglia / physiology*
Neuronal Plasticity / physiology*
Retinal Ganglion Cells / physiology
Synapses / physiology*
Grant Support
ID/Acronym/Agency:
F32 NS066698-01A1/NS/NINDS NIH HHS; F32 NS066698-02/NS/NINDS NIH HHS; F32-NS-066698/NS/NINDS NIH HHS; P30-HD-18655/HD/NICHD NIH HHS; R01 NS071008/NS/NINDS NIH HHS; R01 NS071008-01A1/NS/NINDS NIH HHS; R01 NS071008-02/NS/NINDS NIH HHS; R01-DA-15043/DA/NIDA NIH HHS; R01-NS-045500/NS/NINDS NIH HHS; R01-NS-07100801/NS/NINDS NIH HHS; R01-NS-32151/NS/NINDS NIH HHS; T32 MH020017/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Macrophage-1 Antigen
Comments/Corrections
Comment In:
Neuron. 2012 May 24;74(4):597-9   [PMID:  22632716 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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