| Microglia - insights into immune system structure, function, and reactivity in the central nervous system. | |
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MedLine Citation:
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PMID: 21360445 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Microglia are essential cellular components of a well-functioning central nervous system (CNS). The development and establishment of the microglial population differs from the other major cell populations in the CNS i.e. neurons and macroglia (astrocytes and oligodendrocytes). This different ontogeny gives microglia unique properties. In recent years detailed studies of the microglial population have been greatly facilitated by the use of bone marrow (BM) chimeric animals. Experimental BM transplants have provided the opportunity to trace and investigate how BM cells migrate into the CNS and settle to become microglia. Furthermore various functional properties of microglia in the normal and pathological CNS are now being revealed because of combinations of BM transplantations and experimental disease models. Here, we describe some of the latest findings in microglial biology and discuss the potential for using microglia in therapeutic interventions. |
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Authors:
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M Wirenfeldt; A A Babcock; H V Vinters |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Histology and histopathology Volume: 26 ISSN: 1699-5848 ISO Abbreviation: Histol. Histopathol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8609357 Medline TA: Histol Histopathol Country: Spain |
Other Details:
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Languages: eng Pagination: 519-30 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine (Neuropathology), David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. mwirenfeldt@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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