Document Detail

Microglia in normal condition and pathology.
MedLine Citation:
PMID:  19058517     Owner:  NLM     Status:  MEDLINE    
Microglia, one of three types of glial cells in the central nervous system (CNS), plays an important role as resident immunocompetent and phagocytic cells in CNS in the event of injury and disease. It was del Rio Hortego who in 1927 determined that microglia belong a distinct glial cell type apart from astrocytes and oligodendrocytes. Since 1970s there has been wide recognition that microglial cells are immune effectors in the CNS that respond to pathological conditions and participate in initiation and progression of neurological disorders including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and acquired immune deficiency syndrome dementia complex by releasing potentially cytotoxic molecules such as proinflammatory cytokine, reactive oxygen intermediates, proteinases and complement proteins. There is also evidence to suggest that microglia is capable of secreting neurotrophic or neuron survival factors upon activation during inflammation or injury. It is thus timely to review the current status of knowledge on origin, morphology and functional features of microglial cells.
T A Pivneva
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Fiziolohichnyĭ zhurnal (Kiev, Ukraine : 1994)     Volume:  54     ISSN:  -     ISO Abbreviation:  Fiziol Zh     Publication Date:  2008  
Date Detail:
Created Date:  2008-12-08     Completed Date:  2009-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9601541     Medline TA:  Fiziol Zh     Country:  Ukraine    
Other Details:
Languages:  eng     Pagination:  81-9     Citation Subset:  IM    
O.O. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv.
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MeSH Terms
Brain Diseases* / metabolism,  pathology
Cells, Cultured
Chemokines / metabolism
Microglia* / metabolism,  physiology,  ultrastructure
Phagocytosis / physiology
Reg. No./Substance:

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