Document Detail


Microglia as a unique cellular target in the treatment of stroke: potential neurotoxic mediators produced by activated microglia.
MedLine Citation:
PMID:  7477737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The sequalae evoked by an initial ischemic event in the CNS are incredibly complex and involve a wide range of short-term and long-term metabolic adaptations. With regard to the 'penumbra' area, in which cell death occurs over a 1 to 3 day period, defining the roles of potential neurotoxic mediators is crucial. In this regard, upon cellular activation after an ischemic episode, microglia, the resident macrophages of the CNS, can produce large quantities of a number of neurotoxic mediators. These factors include excitatory amino acids, proteases, cytokinases and nitric oxides. In this manuscript, these mediators are reviewed with regard to the potential utility of suppression of microglial function, via immunosuppressive agents, in the treatment of stroke.
Authors:
P L Wood
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurological research     Volume:  17     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-12-27     Completed Date:  1995-12-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  242-8     Citation Subset:  IM    
Affiliation:
CoCensys Inc., Irvine, CA 92718, USA.
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MeSH Terms
Descriptor/Qualifier:
Cell Communication / drug effects
Cell Death / drug effects
Cerebrovascular Disorders / drug therapy*,  immunology
Cytokines / metabolism
Endopeptidases / metabolism
Excitatory Amino Acids / metabolism
Humans
Microglia / drug effects*,  immunology,  metabolism
Neurons / drug effects*,  pathology
Chemical
Reg. No./Substance:
0/Cytokines; 0/Excitatory Amino Acids; EC 3.4.-/Endopeptidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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