Document Detail

Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis.
MedLine Citation:
PMID:  20887954     Owner:  NLM     Status:  MEDLINE    
In the adult hippocampus, neuroprogenitor cells in the subgranular zone (SGZ) of the dentate gyrus give rise to newborn neuroblasts. However, only a small subset of these cells integrates into the hippocampal circuitry as mature neurons at the end of a 4 week period. Here, we show that the majority of the newborn cells undergo death by apoptosis in the first 1 to 4 days of their life, during the transition from amplifying neuroprogenitors to neuroblasts. These apoptotic newborn cells are rapidly cleared out through phagocytosis by unchallenged microglia present in the adult SGZ niche. Phagocytosis by the microglia is efficient and undeterred by increased age or inflammatory challenge. Our results suggest that the main critical period of newborn cell survival occurs within a few days of birth and reveal a new role for microglia in maintaining the homeostasis of the baseline neurogenic cascade.
Amanda Sierra; Juan M Encinas; Juan J P Deudero; Jessica H Chancey; Grigori Enikolopov; Linda S Overstreet-Wadiche; Stella E Tsirka; Mirjana Maletic-Savatic
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Cell stem cell     Volume:  7     ISSN:  1875-9777     ISO Abbreviation:  Cell Stem Cell     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-03-16     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  101311472     Medline TA:  Cell Stem Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  483-95     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Hippocampus / cytology*
Mice, Transgenic
Neural Stem Cells / cytology
Grant Support
K08 NS044276/NS/NINDS NIH HHS; K08 NS044276-05/NS/NINDS NIH HHS; K08NS0044276/NS/NINDS NIH HHS; P30 HD024064/HD/NICHD NIH HHS; P30HD024064/HD/NICHD NIH HHS; R01 NS042168/NS/NINDS NIH HHS; R01 NS042168-07/NS/NINDS NIH HHS; R01 NS042168-08/NS/NINDS NIH HHS; R01 NS042168-09/NS/NINDS NIH HHS; R21 NS053875/NS/NINDS NIH HHS; R21 NS053875-02/NS/NINDS NIH HHS; R21NS05875-1/NS/NINDS NIH HHS
Comment In:
Cell Stem Cell. 2010 Oct 8;7(4):421-2   [PMID:  20887944 ]

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