| Microfluidic large-scale integration: the evolution of design rules for biological automation. | |
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MedLine Citation:
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PMID: 17269901 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microfluidic large-scale integration (mLSI) refers to the development of microfluidic chips with thousands of integrated micromechanical valves and control components. This technology is utilized in many areas of biology and chemistry and is a candidate to replace today's conventional automation paradigm, which consists of fluid-handling robots. We review the basic development of mLSI and then discuss design principles of mLSI to assess the capabilities and limitations of the current state of the art and to facilitate the application of mLSI to areas of biology. Many design and practical issues, including economies of scale, parallelization strategies, multiplexing, and multistep biochemical processing, are discussed. Several microfluidic components used as building blocks to create effective, complex, and highly integrated microfluidic networks are also highlighted. |
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Authors:
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Jessica Melin; Stephen R Quake |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Annual review of biophysics and biomolecular structure Volume: 36 ISSN: 1056-8700 ISO Abbreviation: Annu Rev Biophys Biomol Struct Publication Date: 2007 |
Date Detail:
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Created Date: 2007-05-04 Completed Date: 2007-08-09 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 9211097 Medline TA: Annu Rev Biophys Biomol Struct Country: United States |
Other Details:
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Languages: eng Pagination: 213-31 Citation Subset: IM |
Affiliation:
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Department of Bioengineering, Stanford University and Howard Hughes Medical Institute, Stanford, California 94305, USA. melin@stanford.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Automation Biochemistry / methods Biophysics / methods* Cell Line DNA, Complementary / metabolism Dimethylpolysiloxanes / chemistry Equipment Design Humans Mice Microfluidic Analytical Techniques* Microfluidics / methods* Models, Biological Models, Theoretical RNA, Messenger / metabolism Silicones / chemistry |
| Grant Support | |
ID/Acronym/Agency:
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1R01 HG002644-01A1/HG/NHGRI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA, Complementary; 0/Dimethylpolysiloxanes; 0/RNA, Messenger; 0/Silicones; 63148-62-9/baysilon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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