Document Detail

Microfluidic emulsification and sorting assisted preparation of monodisperse chitosan microparticles.
MedLine Citation:
PMID:  19209347     Owner:  NLM     Status:  MEDLINE    
A microfluidic device for generating monodisperse chitosan microparticles and separating the desired particle from smaller particles created as a byproduct of this process was described. The purpose of this study is to separate the satellite droplets from their parent droplets to enhance the size uniformity of the desired microparticles. A double T-junction design was first employed to control the emulsification and the separation, respectively. The results show that the size and gap of the parent droplets are tunable by adjusting the water and oil flow rates. A separation ratio of the satellite droplets of more than 99% was observed. The proposed microfluidic chip is capable of generating relatively uniform micro-droplets with well controllable diameter, and it has the added advantages of being a simple, low cost, and high throughput process. In the future this apparatus can be used to fabricate size-controlled monodisperse microparticles to act as drug carriers for biotechnology and biomedicine applications.
Chih-Hui Yang; Yung-Sheng Lin; Keng-Shiang Huang; Yu-Che Huang; Eng-Chi Wang; Jia-Ying Jhong; Chun-Yen Kuo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-21
Journal Detail:
Title:  Lab on a chip     Volume:  9     ISSN:  1473-0197     ISO Abbreviation:  Lab Chip     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-11     Completed Date:  2009-03-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128948     Medline TA:  Lab Chip     Country:  England    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
Department of Biological Science & Technology, I-Shou University, Taiwan.
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MeSH Terms
Chitosan / chemistry*
Reg. No./Substance:
0/Emulsions; 9012-76-4/Chitosan

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