| Microfluidic devices for modeling cell-cell and particle-cell interactions in the microvasculature. | |
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MedLine Citation:
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PMID: 21763328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell-fluid and cell-cell interactions are critical components of many physiological and pathological conditions in the microvasculature. Similarly, particle-cell interactions play an important role in targeted delivery of therapeutics to tissue. Development of in vitro fluidic devices to mimic these microcirculatory processes has been a critical step forward in our understanding of the inflammatory process, developing of nano-particulate drug carriers, and developing realistic in vitro models of the microvasculature and its surrounding tissue. However, widely used parallel plate flow based devices and assays have a number of important limitations for studying the physiological conditions in vivo. In addition, these devices are resource hungry and time consuming for performing various assays. Recently developed, more realistic, microfluidic based devices have been able to overcome many of these limitations. In this review, an overview of the fluidic devices and their use in studying the effects of shear forces on cell-cell and cell-particle interactions is presented. In addition, use of mathematical models and computational fluid dynamics (CFD) based models for interpreting the complex flow patterns in the microvasculature is highlighted. Finally, the potential of 3D microfluidic devices and imaging for better representing in vivo conditions under which cell-cell and cell-particle interactions take place is discussed. |
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Authors:
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Balabhaskar Prabhakarpandian; Ming-Che Shen; Kapil Pant; Mohammad F Kiani |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2011-07-02 |
Journal Detail:
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Title: Microvascular research Volume: 82 ISSN: 1095-9319 ISO Abbreviation: Microvasc. Res. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-14 Completed Date: 2012-03-13 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0165035 Medline TA: Microvasc Res Country: United States |
Other Details:
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Languages: eng Pagination: 210-20 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Biomedical Technology, CFD Research Corporation, 215 Wynn Dr., Huntsville, AL 35805, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Adhesion* Cell Communication* Computer Simulation Equipment Design Hemorheology* Humans Microcirculation* Microfluidic Analytical Techniques / instrumentation* Microvessels / cytology, physiology* Models, Cardiovascular |
| Grant Support | |
ID/Acronym/Agency:
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R43 CA139841-01/CA/NCI NIH HHS; R44 HL076034-02/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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