Document Detail


Microfine zinc oxide (Z-cote) as a photostable UVA/UVB sunblock agent.
MedLine Citation:
PMID:  9922017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Microfine zinc oxide (Z-Cote) is used as a transparent broad-spectrum sunblock to attenuate UV radiation (UVR), including UVA I (340-400 nm). OBJECTIVE: Our purpose was to assess the suitability of microfine zinc oxide as a broad-spectrum photoprotective agent by examining those properties generally considered important in sunscreens: attenuation spectrum, sun protection factor (SPF) contribution, photostability, and photoreactivity. METHODS: Attenuation spectrum was assessed by means of standard spectrophotometric methods. SPF contribution was evaluated according to Food and Drug Administration standards. Photostability was measured in vitro by assessing SPF before and after various doses of UVR. Photoreactivity was evaluated by subjecting a microfine zinc oxide/organic sunscreen formulation to escalating doses of UVR and determining the percentage of organic sunscreen remaining. RESULTS: Microfine zinc oxide attenuates throughout the UVR spectrum, including UVA I. It is photostable and does not react with organic sunscreens under irradiation. CONCLUSION: Microfine zinc oxide is an effective and safe sunblock that provides broad-spectrum UV protection, including protection from long-wavelength UVA.
Authors:
M A Mitchnick; D Fairhurst; S R Pinnell
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  40     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-02-18     Completed Date:  1999-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  85-90     Citation Subset:  IM    
Affiliation:
sunSmart Inc, Wainscott, New York, USA.
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MeSH Terms
Descriptor/Qualifier:
Humans
Particle Size
Spectrophotometry
Sunscreening Agents / chemistry,  pharmacology*
Titanium / chemistry,  pharmacology
Zinc Oxide / chemistry,  pharmacology*
Chemical
Reg. No./Substance:
0/Sunscreening Agents; 1314-13-2/Zinc Oxide; 13463-67-7/titanium dioxide; 7440-32-6/Titanium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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