Document Detail

Microfilariae in the cerebrospinal fluid, and neurological complications, during treatment of onchocerciasis with diethylcarbamazine.
MedLine Citation:
PMID:  941247     Owner:  NLM     Status:  MEDLINE    
Microfilariae of Onchocerca volvulus were found in the cerebrospinal fluid (CSF) of 5/8 heavily infected onchocerciasis patients. During treatment with diethylcarbamazine citrate 10/11 patients showed increased numbers of 0. volvulus microfilariae in the CSF. Patients with concentrations of 8-31 mf/ml CSF developed severe vertigo, and some other neurological manifestations, during treatment. A hypothesis is put forward to account for this clinical piciture, and its importance in relation to the treatment of onchocerciasis is discussed.
B O Duke; J Vincelette; P J Moore
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tropenmedizin und Parasitologie     Volume:  27     ISSN:  0303-4208     ISO Abbreviation:  Tropenmed Parasitol     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-09-25     Completed Date:  1976-09-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0423216     Medline TA:  Tropenmed Parasitol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  123-32     Citation Subset:  IM    
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MeSH Terms
Blood-Brain Barrier / drug effects
Cerebrospinal Fluid / parasitology*
Choroid Plexus / metabolism
Diethylcarbamazine / adverse effects*,  pharmacology,  therapeutic use
Neurologic Manifestations
Onchocerciasis / blood,  drug therapy*
Skin / parasitology
Suramin / therapeutic use
Vertigo / etiology*
Reg. No./Substance:
145-63-1/Suramin; 90-89-1/Diethylcarbamazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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