Document Detail


Microfabrication and nanotechnology in stent design.
MedLine Citation:
PMID:  21462356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intravascular stents were first introduced in the 1980s as an adjunct to primary angioplasty for management of early complications, including arterial dissection, or treatment of an inadequate technical outcome due to early elastic recoil of the atherosclerotic lesion. Despite the beneficial effects of stenting, persistent high rates of restenosis motivated the design of drug-eluting stents for delivery of agents to limit the proliferative and other inflammatory responses within the vascular wall that contribute to the development of a restenotic lesion. These strategies have yielded a significant reduction in the incidence of restenosis, but challenges remain, including incomplete repair of the endothelium at the site of vascular wall injury that may be associated with a late risk of thrombosis. A failure of vessel wall healing has been attributed primarily to the use of polymeric stent coatings, but the effects of the eluted drug and other material properties or design features of the stent cannot be excluded. Improvements in stent microfabrication, as well as the introduction of alternative materials may help to address those limitations that inhibit stent performance. This review describes the application of novel microfabrication processes and the evolution of new nanotechnologies that hold significant promise in eliminating existing shortcomings of current stent platforms.
Authors:
Adam W Martinez; Elliot L Chaikof
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-01-31
Journal Detail:
Title:  Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology     Volume:  3     ISSN:  1939-0041     ISO Abbreviation:  Wiley Interdiscip Rev Nanomed Nanobiotechnol     Publication Date:    2011 May-Jun
Date Detail:
Created Date:  2011-04-04     Completed Date:  2011-09-30     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101508311     Medline TA:  Wiley Interdiscip Rev Nanomed Nanobiotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  256-68     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 John Wiley & Sons, Inc.
Affiliation:
Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biopharmaceutics
Microtechnology / methods*
Nanotechnology / methods*
Prosthesis Design*
Stents*
Surface Properties
Grant Support
ID/Acronym/Agency:
R01 HL056819/HL/NHLBI NIH HHS; R01 HL083867/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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