Document Detail


Microfabricated mammalian organ systems and their integration into models of whole animals and humans.
MedLine Citation:
PMID:  23388858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
While in vitro cell based systems have been an invaluable tool in biology, they often suffer from a lack of physiological relevance. The discrepancy between the in vitro and in vivo systems has been a bottleneck in drug development process and biological sciences. The recent progress in microtechnology has enabled manipulation of cellular environment at a physiologically relevant length scale, which has led to the development of novel in vitro organ systems, often termed 'organ-on-a-chip' systems. By mimicking the cellular environment of in vivo tissues, various organ-on-a-chip systems have been reported to reproduce target organ functions better than conventional in vitro model systems. Ultimately, these organ-on-a-chip systems will converge into multi-organ 'body-on-a-chip' systems composed of functional tissues that reproduce the dynamics of the whole-body response. Such microscale in vitro systems will open up new possibilities in medical science and in the pharmaceutical industry.
Authors:
Jong H Sung; Mandy B Esch; Jean-Matthieu Prot; Christopher J Long; Alec Smith; James J Hickman; Michael L Shuler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Lab on a chip     Volume:  13     ISSN:  1473-0189     ISO Abbreviation:  Lab Chip     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-05     Completed Date:  2013-08-29     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  101128948     Medline TA:  Lab Chip     Country:  England    
Other Details:
Languages:  eng     Pagination:  1201-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animal Structures* / cytology,  metabolism,  physiology
Animals
Biomimetics / methods*
Humans
Mammals*
Microtechnology / methods*
Grant Support
ID/Acronym/Agency:
R01 NS050452/NS/NINDS NIH HHS; R01EB009429/EB/NIBIB NIH HHS; R01NS050452/NS/NINDS NIH HHS
Comments/Corrections

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