Document Detail

Microfabricated glucose biosensor with glucose oxidase entrapped in sol-gel matrix.
MedLine Citation:
PMID:  18967378     Owner:  NLM     Status:  In-Data-Review    
A microfabricated glucose biosensor based on an amperometeric hydrogen peroxide electrode has been developed. A sol-gel layer with 5 A pore size and 2 mum thickness was used as the glucose oxidase entrapping matrix. The sol-gel matrix formed over the silicon-based sensor has good mechanical and chemical stability, and the ability to entrap a large amount of enzyme. The miniaturized electrode sensing system is composed of platinum as both working and counter electrodes and silver as a reference electrode. Nafion(R) coating was applied as the interference limiting layer. A series of technologies, such as standard photolithography, electron beam evaporation and image reverse lift-off were utilized for mass production allowing 143 electrodes to be produced at the same time. The effect of oxidable interferences was <10% of the background value of the sensor response. Calibration tests of a series of individual sensors manufactured from the same silicon wafer and dip coated in the same conditions, showed a highly reproducible response characteristics (linear range up to 500 mg dl(-1) and mean sensitivity of 0.54+/-0.14 nA mg(-1) dl(-1) (n=10)).
S Yang; Y Lu; P Atanossov; E Wilkins; X Long
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Talanta     Volume:  47     ISSN:  0039-9140     ISO Abbreviation:  Talanta     Publication Date:  1998 Nov 
Date Detail:
Created Date:  2008-10-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984816R     Medline TA:  Talanta     Country:  England    
Other Details:
Languages:  eng     Pagination:  735-43     Citation Subset:  -    
Chemical and Nuclear Engineering Department, The University of New Mexico, Albuquerque, NM 87131-1341, USA.
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