Document Detail

Microenvironment of Woringer-Kolopp's disease.
MedLine Citation:
PMID:  7067876     Owner:  NLM     Status:  MEDLINE    
A localized form of 'Pagetoid reticulosis' (Woringer-Kolopp's disease) is described morphologically. It can be shown that ultrastructurally the 'Pagetoid cells' are heterogenic and that different cell types can be distinguished: there are lymphoid cells, which often look like Lutzner cells, and nonlymphoid cells which can be characterized as indeterminate cells or Langerhans' cells. Often a close topographical relation between lymphoid and nonlymphoid cells can be demonstrated. This finding is suggestive for a functional interaction between the lymphoid cells, which are most probably T cells, and indeterminate cells and Langerhans' cells, which are known to be important for the thymus-dependent immune reaction. The presence of the nonlymphoid cell population in the epidermis in Woringer-Kolopp's disease seems to build up the specific microenvironment for lymphoid cell reaction.
M L Geerts; E Kaiserling; A Kint
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Dermatologica     Volume:  164     ISSN:  0011-9075     ISO Abbreviation:  Dermatologica     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-06-14     Completed Date:  1982-06-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0211607     Medline TA:  Dermatologica     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  15-29     Citation Subset:  IM    
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MeSH Terms
Epidermis / enzymology,  ultrastructure*
Langerhans Cells / enzymology,  ultrastructure
Lymphocytes / ultrastructure
Middle Aged
Mycosis Fungoides / pathology
Skin Diseases / enzymology,  pathology*
Skin Neoplasms / pathology

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