Document Detail


Microencapsulation and modification of synthetic peptides of food proteins reduces the blood pressure of spontaneously hypertensive rats.
MedLine Citation:
PMID:  12617603     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Synthetic peptides were microencapsulated into liposomes, cycled with a disulfide bond or modified with d-phenylglycine (d-phg) at the N-terminal, and their antihypertensive effects as orally administered (0.18 mM/kg body weight) to spontaneously hypertensive rats (SHR) were measured. The microencapsulated Leu-Lys-Pro reduced significantly the systolic blood pressures of SHR by 45 mmHg and showed a prolonged duration, revealing the significant protective effect of encapsulation. d-phg-Leu-Arg-Pro showed a duration about 2 h shorter than that of the peptide without modification. In addition, cyclic Leu-Arg-Pro peptide with a disulfide bond between the N- and C-terminal amino acids reduced the systolic blood pressure of SHR by 35 mmHg and displayed a lengthy duration.
Authors:
Tzy-Li Chen; Yung-Chieh Lo; Wei-Tze Hu; Ming-Chang Wu; Shui-Ten Chen; Hung-Min Chang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  51     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-05     Completed Date:  2004-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1671-5     Citation Subset:  IM    
Affiliation:
Graduate Institute of Food Science & Technology, National Taiwan University, Taipei 106-17, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Angiotensin-Converting Enzyme Inhibitors / administration & dosage
Animals
Antihypertensive Agents / administration & dosage*
Blood Pressure / drug effects*
Captopril / pharmacology
Dietary Proteins / analysis*
Hydrolysis
Kinetics
Liposomes / chemistry*
Peptides / administration & dosage*,  chemistry*
Peptides, Cyclic / administration & dosage,  chemistry
Rats
Rats, Inbred SHR
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Dietary Proteins; 0/Liposomes; 0/Peptides; 0/Peptides, Cyclic; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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