Document Detail

Microembolic signals within 24 hours of stroke onset and diffusion-weighted MRI abnormalities.
MedLine Citation:
PMID:  17199085     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The clinical relevance of the microembolic signals (MES) detected by transcranial Doppler sonography (TCD) in acute stroke remains unclear. In a prospective study the authors analyzed the relationship between MES and the findings on diffusion-weighted magnetic resonance imaging (DWI) in acute stroke patients. METHODS: We performed TCD for a period of 30 min to detect MES in patients within 24 h of stroke onset, and DWI was done within the initial 7 days. MES were assessed from Doppler waves obtained from the middle cerebral artery contralateral to the side of the neurological deficits. The acute ischemic lesions observed on DWI were classified by their diameter (small, medium or large) and by their site (cortical, superficial perforator territory, internal borderzone or deep perforator territory). RESULTS: We obtained Doppler waves from 39 vessels in 37 patients; 2 patients had bilateral deficits. MES were detected in 12 vessels (MES-positive group) and not detected in 27 vessels (MES-negative group). No significant differences in clinical features were observed between the 2 groups. The number of small lesions was significantly higher in the MES-positive group than in the MES-negative group (p = 0.02). The numbers of cortical and superficial perforator infarcts were significantly higher in the MES-positive group than in the MES-negative group (p = 0.002 and 0.02, respectively). CONCLUSION: In acute ischemic stroke, MES detected by TCD in the acute phase may produce small cortical and subcortical lesions found on DWI.
Makoto Nakajima; Kazumi Kimura; Atsuko Shimode; Fumio Miyashita; Makoto Uchino; Hiroaki Naritomi; Kazuo Minematsu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-29
Journal Detail:
Title:  Cerebrovascular diseases (Basel, Switzerland)     Volume:  23     ISSN:  1015-9770     ISO Abbreviation:  Cerebrovasc. Dis.     Publication Date:  2007  
Date Detail:
Created Date:  2007-03-14     Completed Date:  2007-04-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9100851     Medline TA:  Cerebrovasc Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  282-8     Citation Subset:  IM    
Copyright Information:
(c) 2007 S. Karger AG, Basel.
Cerebrovascular Division, Department of Medicine, National Cardiovascular Center, Osaka, Japan.
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MeSH Terms
Acute Disease
Aged, 80 and over
Brain Ischemia / complications,  diagnosis,  etiology,  pathology*
Diffusion Magnetic Resonance Imaging*
Intracranial Embolism / complications,  diagnosis,  pathology*
Ischemic Attack, Transient / diagnosis,  etiology,  pathology
Middle Aged
Middle Cerebral Artery / pathology*
Prospective Studies
Stroke / diagnosis,  etiology,  pathology*
Telencephalon / pathology
Time Factors
Ultrasonography, Doppler, Transcranial

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