| Microembolic signals in acute posterior circulation cerebral ischemia: sources and consequences. | |
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MedLine Citation:
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PMID: 22343653 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: The clinical significance of microembolic signals (MES) in the posterior circulation remains unclear. The aim of this study was to investigate the sources and consequences of MES in acute posterior circulation cerebral ischemia. METHODS: We evaluated a total of 140 consecutive patients (93 males, mean age 62.9 years) who had acute posterior circulation cerebral ischemia. The MES monitoring was conducted at the basilar artery through the suboccipital window for a 30-minute period. RESULTS: MES were detected in 18 (12.9%) of the 140 patients. Clinical characteristics and laboratory data did not differ between the MES-positive and MES-negative groups. Intracranial vertebrobasilar artery (VBA) stenosis was independently associated with the presence of MES (odds ratio, 9.85; 95% confidence interval, 1.22-79.48; P=0.032), whereas the patients with vertebral artery stenosis that was limited to the extracranial portion did not show an association. Microembolic signals occurred significantly more frequently in patients with severe degree of VBA stenosis compared to those with nonsignificant stenosis (odds ratio, 9.88; 95% confidence interval, 1.23-79.07; P=0.031). In a subgroup analysis of the 79 patients who had lesions on diffusion-weighted images and relevant VBA stenosis, the MES-positive group showed more frequent embolic infarction (P=0.010) and multiple lesion patterns (P=0.007) than single perforating infarctions. CONCLUSIONS: In acute posterior circulation cerebral ischemia, intracranial and severe VBA stenosis is associated with MES and may be its root causes. The presence of MES in VBA stenosis suggests that multiple and embolic type infarctions are the mechanisms of stroke. |
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Authors:
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Jaechun Hwang; Suk Jae Kim; Ji Man Hong; Oh Young Bang; Chin-Sang Chung; Kwang Ho Lee; Gyeong-Moon Kim |
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Publication Detail:
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Type: Journal Article Date: 2012-02-16 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 43 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 747-52 Citation Subset: IM |
Affiliation:
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Department of Neurology, Samsung Medical Center, Sungkyunkwan University 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, South Korea. kimgm@skku.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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