Document Detail

Microdialysis sampling for hepatic metabolism studies. Impact of microdialysis probe design and implantation technique on liver tissue.
MedLine Citation:
PMID:  8654194     Owner:  NLM     Status:  MEDLINE    
Microdialysis sampling of liver tissue was performed using several probe geometries. The extent of tissue damage and response in vivo caused by implantation and indwelling of the probe was evaluated by histological examination of the tissue. A linear probe, implanted using fused silica tubing, was less damaging than other probe designs and implantation procedures tested. A series of time points up to 48 hr after implantation ere histologically examined. Infiltration of inflammatory cells, predominantly polymorphonuclear leukocytes (PMNs), was evident adjacent to the probe membrane after approximately 8 hr. Mixed inflammatory infiltration, mainly PMNs but including some macrophages, was observed in tissue slices 18 hr after implantation. At 48 hr, the mixed inflammatory infiltration was still present, with some degeneration of PMNs. In implantations of longer than 12 hr, some necrosis appeared at eh implantation site. The rate of delivery of phenol via the probe was stable for at least 30 hr, despite changes in the surrounding tissue.
M I Davies; C E Lunte
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Drug metabolism and disposition: the biological fate of chemicals     Volume:  23     ISSN:  0090-9556     ISO Abbreviation:  Drug Metab. Dispos.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-07-26     Completed Date:  1996-07-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421550     Medline TA:  Drug Metab Dispos     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1072-9     Citation Subset:  IM    
Department of Chemistry, University of Kansas, Lawrence 66045, USA.
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MeSH Terms
Liver / metabolism*,  pathology
Microdialysis / methods*
Rats, Sprague-Dawley
Grant Support

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