| Microdialysis microneedles for continuous medical monitoring. | |
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MedLine Citation:
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PMID: 15834522 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Enzyme based biosensors suffer from loss of activity and sensitivity through a variety of processes. One major reason for the loss is through large molecular weight proteins settling onto the sensor and affecting sensor signal stability and disrupting enzyme function. One way to minimize loss of sensor activity is to filter out large molecular weight compounds before sensing small biochemicals such as glucose. A novel microdialysis microneedle is introduced that is capable of excluding large MW compounds based on size. Preliminary experimental evidence of membrane permeability is shown, as well as diffusion and permeability modeling. Microdialysis microneedles present an attractive first step towards decreasing size, patient discomfort and energy consumption of portable medical monitors over existing technologies. |
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Authors:
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Jeffrey D Zahn; David Trebotich; Dorian Liepmann |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Biomedical microdevices Volume: 7 ISSN: 1387-2176 ISO Abbreviation: Biomed Microdevices Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-04-18 Completed Date: 2005-08-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100887374 Medline TA: Biomed Microdevices Country: United States |
Other Details:
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Languages: eng Pagination: 59-69 Citation Subset: IM |
Affiliation:
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Berkeley Sensor and Actuator Center, University of California, Berkeley, 497 Cory Hall, Berkeley, CA 94720-1774, USA. jdz10@psu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Equipment Design Equipment Failure Analysis Microdialysis / instrumentation*, methods Microfluidics / instrumentation*, methods Monitoring, Physiologic / instrumentation*, methods Needles* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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