Document Detail

Microdialysis and electromyography of experimental muscle fatigue in healthy volunteers and patients with mitochondrial myopathy.
MedLine Citation:
PMID:  12362418     Owner:  NLM     Status:  MEDLINE    
Consecutive 60-min microdialysis samples were taken from the tibial anterior muscle in 11 healthy subjects and 4 patients with mitochondrial myopathy before (2-3 samples) and after (3-4 samples, 2 controls and 1 patient excluded) sustained isometric foot dorsiflexions. Before exercise, mean concentrations of lactate, pyruvate, hypoxanthine, urate, aspartate, and glutamate did not significantly differ between controls and patients. After exercise, the controls showed significantly increased concentrations of lactate, pyruvate, and urate, decreased hypoxanthine, and no change in aspartate and glutamate. Similar findings were observed in the patients. Plasma lactate was unchanged. Exercise-induced increase in integrated electromyogram amplitude and rated subjective fatigue were correlated to increased post-exercise lactate concentrations, with no obvious difference between the groups. Microdialysis of skeletal muscle allows the detection and monitoring of biochemical changes in the interstitial space. With the exercise protocol used, however, it was not possible to demonstrate any biochemical difference between healthy controls and patients with mitochondrial myopathy.
Hans W Axelson; Atle Melberg; Gunnar Ronquist; Håkan Askmark
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Muscle & nerve     Volume:  26     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-03     Completed Date:  2002-10-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  520-6     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley Periodicals, Inc. Muscle Nerve 26:520-526, 2002
Department of Neuroscience, Uppsala University Hospital, S-751 85 Uppsala, Sweden.
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MeSH Terms
Aconitate Hydratase / deficiency
Exercise / physiology
Isometric Contraction / physiology
Lactic Acid / metabolism
Mitochondrial Myopathies / metabolism*,  physiopathology*
Muscle Fatigue / physiology*
Muscle, Skeletal / metabolism,  physiopathology
Pyruvic Acid / metabolism
Succinate Dehydrogenase / deficiency
Reg. No./Substance:
127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; EC Dehydrogenase; EC Hydratase

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