| Microdialysis and electromyography of experimental muscle fatigue in healthy volunteers and patients with mitochondrial myopathy. | |
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MedLine Citation:
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PMID: 12362418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Consecutive 60-min microdialysis samples were taken from the tibial anterior muscle in 11 healthy subjects and 4 patients with mitochondrial myopathy before (2-3 samples) and after (3-4 samples, 2 controls and 1 patient excluded) sustained isometric foot dorsiflexions. Before exercise, mean concentrations of lactate, pyruvate, hypoxanthine, urate, aspartate, and glutamate did not significantly differ between controls and patients. After exercise, the controls showed significantly increased concentrations of lactate, pyruvate, and urate, decreased hypoxanthine, and no change in aspartate and glutamate. Similar findings were observed in the patients. Plasma lactate was unchanged. Exercise-induced increase in integrated electromyogram amplitude and rated subjective fatigue were correlated to increased post-exercise lactate concentrations, with no obvious difference between the groups. Microdialysis of skeletal muscle allows the detection and monitoring of biochemical changes in the interstitial space. With the exercise protocol used, however, it was not possible to demonstrate any biochemical difference between healthy controls and patients with mitochondrial myopathy. |
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Authors:
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Hans W Axelson; Atle Melberg; Gunnar Ronquist; Håkan Askmark |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Muscle & nerve Volume: 26 ISSN: 0148-639X ISO Abbreviation: Muscle Nerve Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-03 Completed Date: 2002-10-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
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Languages: eng Pagination: 520-6 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Wiley Periodicals, Inc. Muscle Nerve 26:520-526, 2002 |
Affiliation:
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Department of Neuroscience, Uppsala University Hospital, S-751 85 Uppsala, Sweden. hans.axelson@nc.uas.lul.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aconitate Hydratase
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deficiency Adolescent Adult Aged Electromyography Exercise / physiology Female Humans Isometric Contraction / physiology Lactic Acid / metabolism Male Microdialysis Mitochondrial Myopathies / metabolism*, physiopathology* Muscle Fatigue / physiology* Muscle, Skeletal / metabolism, physiopathology Pyruvic Acid / metabolism Succinate Dehydrogenase / deficiency |
| Chemical | |
Reg. No./Substance:
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127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; EC 1.3.99.1/Succinate Dehydrogenase; EC 4.2.1.3/Aconitate Hydratase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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