Document Detail

Microcytosis and iron status in dogs with surgically induced portosystemic shunts.
MedLine Citation:
PMID:  8064657     Owner:  NLM     Status:  MEDLINE    
Microcytosis is common in dogs with congenital portosystemic shunts (PSS) and acquired liver disease. The objective of this study was to determine if microcytosis could be induced in normal dogs by surgical creation of PSS, and to characterize the changes in hematology and iron status. Hematocrit, mean cell volume, mean cell hemoglobin, and mean cell hemoglobin concentration decreased linearly from 45.5%, 69.1 fL, 22.8 g/dL and 33.1% to 39.5%, 55.9 fL, 17.8 g/dL and 31.9%, respectively, 18 weeks after creation of PSS. The erythrocyte count did not change, but red cell distribution widths indicated a shift to a heterogenous population with decreased volume. Mean cell volume and mean cell hemoglobin decreased rapidly after induction of PSS and were significantly (P < .05) different from presurgery values within 2 weeks. Serum iron and copper concentrations and total iron binding capacity were decreased in dogs with PSS. Liver iron concentration doubled after creation of PSS, with the majority of stainable iron located in Kupffer cells. The changes in erythrocyte indices and measures of iron status in dogs with surgically induced PSS were similar to those in dogs with congenital PSS. Microcystosis developed rapidly in dogs after induction of PSS. These results indicate that iron deficiency was not the cause of microcytosis in these dogs.
D P Laflamme; E A Mahaffey; S W Allen; D C Twedt; K W Prasse; T L Huber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  8     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    1994 May-Jun
Date Detail:
Created Date:  1994-09-22     Completed Date:  1994-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  212-6     Citation Subset:  IM    
Department of Physiology, University of Georgia, Athens 30602.
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MeSH Terms
Analysis of Variance
Copper / metabolism
Dog Diseases / blood*,  metabolism
Erythrocytes, Abnormal*
Iron / blood*,  metabolism
Liver / metabolism
Portacaval Shunt, Surgical / veterinary*
Time Factors
Transferrin / metabolism
Zinc / metabolism
Reg. No./Substance:
11096-37-0/Transferrin; 7439-89-6/Iron; 7440-50-8/Copper; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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