Document Detail

Microculture model studies on the effect of sorbic acid on Penicillium chrysogenum, Cladosporium cladosporioides and Ulocladium atrum at different pH levels.
MedLine Citation:
PMID:  8444649     Owner:  NLM     Status:  MEDLINE    
The minimum growth-inhibitory concentration of sorbic acid has been determined for Penicillium chrysogenum, Cladosporium cladosporioides and Ulocladium atrum at pH 4.1-7.6 by using a microculture technique. This technique had earlier been applied to bacteria and Candida albicans and gave very reliable minimum inhibitory values. This investigation has shown that it is suitable also for determination of mould growth. The minimum inhibitory concentrations of sorbic acid were at the tested pH levels 1-230 mmol l-1 for P. chrysogenum, 0.3-18.0 mmol l-1 for C. cladosporioides and 0.2-33.0 mmol l-1 for U. atrum. A mathematical model for combined inhibition by dissociated and undissociated acid, which gave a good description of the minimum inhibitory concentration data earlier obtained for bacteria and Candida albicans, was suitable also for moulds. Both dissociated and undissociated acid contributed to growth inhibition.
I M Skirdal; T Eklund
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of applied bacteriology     Volume:  74     ISSN:  0021-8847     ISO Abbreviation:  J. Appl. Bacteriol.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-06     Completed Date:  1993-04-06     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  7503050     Medline TA:  J Appl Bacteriol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  191-5     Citation Subset:  IM    
MATFORSK, Norwegian Food Research Institute, Osloveien, As.
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MeSH Terms
Cladosporium / drug effects*,  growth & development
Dose-Response Relationship, Drug
Hydrogen-Ion Concentration
Mitosporic Fungi / drug effects*,  growth & development
Models, Biological
Penicillium chrysogenum / drug effects*,  growth & development
Regression Analysis
Sorbic Acid / pharmacology*
Reg. No./Substance:
110-44-1/Sorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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