| Microcirculatory events in ischemia/reperfusion of the pancreas defined by continuous tissue oximetry. | |
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MedLine Citation:
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PMID: 11976739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In ischemia/reperfusion of the pancreas impairment of microcirculation after reperfusion is believed to be of critical importance. The 'no-reflow' phenomenon is thought to cause persisting tissue ischemia, while the 'reflow-paradox' is defined as secondary impairment of nutritive perfusion. These phenomena have been shown by intravital microscopy but their effect on tissue oxygenation as assessed by continuous tissue oximetry has not been identified. In landrace pigs tissue oxygenation was investigated in warm ischemia/reperfusion of the pancreas by the use of continuous tissue oximetry. After reperfusion rapid reoxygenation occurred which was followed by a period of secondary hypoxia. Thereafter, secondary reoxygenation was found, and finally tertiary hypoxia with a gradual decline of tissue pO(2) was noted. The data show a relevant impairment of tissue oxygenation after reperfusion. However, 'no-reflow' seems not to be a primary failure of capillary reperfusion but the consequence of a short reperfusion period followed by secondary ischemia. The 'reflow-paradox' most likely corresponds to tertiary ischemia. |
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Authors:
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Stefan Benz; Reiko Wiessner; Robert Obermaier; Frank Pfeffer; Ulrich T Hopt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2002-03-21 |
Journal Detail:
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Title: Transplant international : official journal of the European Society for Organ Transplantation Volume: 15 ISSN: 0934-0874 ISO Abbreviation: Transpl. Int. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-04-26 Completed Date: 2002-10-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8908516 Medline TA: Transpl Int Country: Germany |
Other Details:
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Languages: eng Pagination: 173-9 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Freiburg, Hugstetter Str. 55, 70106 Freiburg, Germany. stefanrolfbenz@web.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Female Ischemia / physiopathology* Microcirculation / physiology* Organ Preservation / methods Oximetry / methods Oxygen / blood Oxygen Consumption Pancreas / blood supply*, metabolism Partial Pressure Regional Blood Flow Reperfusion Swine |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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