Document Detail

Microcirculatory effects of hyperthermia and 5-fluorouracil in the skin of nude mice.
MedLine Citation:
PMID:  8125709     Owner:  NLM     Status:  MEDLINE    
During cancer chemotherapy physical manipulation of skin perfusion by hyperthermia can limit therapeutic efficacy. Because it is important to know microcirculatory responses to those forms of treatment, we used the ear of the lightly or not at all anesthetized nude mouse (rnü/rnü). To test, if whole body hyperthermia (WBH) and 5-fluorouracil (5-FU) acutely affect skin microvessels, we applied red light (group 1). 5-FU was injected prior to WBH, to test for effects of 5-FU on WBH (group 2). Respiratory rate increased and medium sized and small arterioles constricted during WBH in both groups and cutaneous perfusion decreased. 5-FU did not change these results. There were more leucocytes rolling along the vessel wall of small and medium-sized venules after 5-FU treatment (compared to BL). Our data suggest that activation of sympathetic tone by an external heat source compromises skin perfusion and could decrease the amount of cytostatic agents to that organ during WBH. Finally, there is more intense interaction among leucocytes and endothelial cells omit in response to 5-FU.
A S Lübbe; R Herrmann; H Riess; D Huhn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation     Volume:  13     ISSN:  0167-6865     ISO Abbreviation:  Int J Microcirc Clin Exp     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-04-11     Completed Date:  1994-04-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8400122     Medline TA:  Int J Microcirc Clin Exp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  205-17     Citation Subset:  IM    
Department of Medicine (division: Oncology), Kantonspital Basel, Switzerland.
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MeSH Terms
Combined Modality Therapy
Fluorouracil / pharmacology*
Hyperthermia, Induced*
Mice, Nude
Microcirculation / drug effects,  physiology
Neoplasms, Experimental / physiopathology,  therapy*
Skin / blood supply*,  drug effects
Reg. No./Substance:

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