Document Detail


Microcirculatory changes in sodium taurocholate-induced pancreatitis in rats.
MedLine Citation:
PMID:  1996652     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using an in vivo microscopy technique, we studied the microcirculatory changes in sodium taurocholate-induced pancreatitis in rats. With a computerized image analyzer system, blood flow, vascular permeability changes, and capillary densities were measured. Intraductal infusion of 0.4 ml saline had only minor effects on the microcirculation. Various concentrations and volumes of sodium taurocholate solutions were infused into the pancreatic duct. Sodium taurocholate (0.4 ml, 4%) led to increased vascular permeability preceding stasis within 232 +/- 47 s, followed by hemorrhagic necrosis in the head of the pancreas. In the corpus close to the tail of the pancreas capillary blood flow was maintained. In conclusion, this study shows that the microcirculation of the pancreas can be excellently investigated with in vivo microscopy. With this method, tremendous distribution disturbances of the microcirculation in the pancreas can be seen in the course of acute pancreatitis. Vascular permeability changes and stasis of the microcirculation represent the primary microcirculatory events in acute pancreatitis induced by sodium taurocholate in the areas where hemorrhagic necrosis occurs.
Authors:
K Kusterer; M Enghofer; S Zendler; C Blöchle; K H Usadel
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  260     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-03-27     Completed Date:  1991-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G346-51     Citation Subset:  IM    
Affiliation:
Department of Medicine II, University of Heidelberg, Mannheim, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Capillaries / drug effects,  pathology*
Female
Microcirculation / drug effects,  pathology*
Pancreas / blood supply*,  drug effects,  pathology
Pancreatitis / chemically induced,  pathology,  physiopathology*
Rats
Rats, Inbred Strains
Taurocholic Acid / toxicity*
Chemical
Reg. No./Substance:
81-24-3/Taurocholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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