| Microcirculatory changes in sodium taurocholate-induced pancreatitis in rats. | |
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MedLine Citation:
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PMID: 1996652 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using an in vivo microscopy technique, we studied the microcirculatory changes in sodium taurocholate-induced pancreatitis in rats. With a computerized image analyzer system, blood flow, vascular permeability changes, and capillary densities were measured. Intraductal infusion of 0.4 ml saline had only minor effects on the microcirculation. Various concentrations and volumes of sodium taurocholate solutions were infused into the pancreatic duct. Sodium taurocholate (0.4 ml, 4%) led to increased vascular permeability preceding stasis within 232 +/- 47 s, followed by hemorrhagic necrosis in the head of the pancreas. In the corpus close to the tail of the pancreas capillary blood flow was maintained. In conclusion, this study shows that the microcirculation of the pancreas can be excellently investigated with in vivo microscopy. With this method, tremendous distribution disturbances of the microcirculation in the pancreas can be seen in the course of acute pancreatitis. Vascular permeability changes and stasis of the microcirculation represent the primary microcirculatory events in acute pancreatitis induced by sodium taurocholate in the areas where hemorrhagic necrosis occurs. |
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Authors:
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K Kusterer; M Enghofer; S Zendler; C Blöchle; K H Usadel |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 260 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-03-27 Completed Date: 1991-03-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: G346-51 Citation Subset: IM |
Affiliation:
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Department of Medicine II, University of Heidelberg, Mannheim, Federal Republic of Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Capillaries / drug effects, pathology* Female Microcirculation / drug effects, pathology* Pancreas / blood supply*, drug effects, pathology Pancreatitis / chemically induced, pathology, physiopathology* Rats Rats, Inbred Strains Taurocholic Acid / toxicity* |
| Chemical | |
Reg. No./Substance:
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81-24-3/Taurocholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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