| Microcirculatory vascular dysfunction in HIV-1 infected patients receiving highly active antiretroviral therapy. | |
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MedLine Citation:
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PMID: 20536743 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We investigated whether HIV-1 infected patients receiving highly active antiretroviral therapy (HAART) and HIV-1 infected patients who had never received HAART had differences in their vascular microcirculatory function. METHODS: We assessed the forearm blood flow before and after four minutes of ischemic occlusion of the brachial artery using venous occlusion strain gauge plethysmography. The hyperaemic forearm blood flow was recorded for three minutes at 15 second intervals. We calculated the maximal percent increase of the forearm blood flow during hyperemia. Forty HIV-infected male patients receiving HAART were compared to 20 age- and BMI- matched, male HIV-infected patients who had never received HAART (control group). RESULTS: Patients on HAART had similar baseline forearm blood flow but lower maximal and percentage (%) change in forearm blood flow than control patients (4.2 +/- 1.7 vs. 4.1 +/- 1.7 l/ 100mL/min P = 0.8, 32 +/- 11.2 vs. 38.9 +/- 10.5 l/100 mL/min. P = 0.04 and 714 +/- 255 vs. 907 +/- 325%, P = 0.01, respectively). Patients receiving HAART had higher cholesterol than control patients (221 +/- 58 vs. 163 +/- 38 mg/dL, P = 0.001). HAART was associated with the percentage change in the blood flow during hyperemia (coefficient regression B = -0.32, P = 0.02) after adjustment for age, cholesterol and viral load. CONCLUSIONS: HIV-infected patients receiving HAART present abnormalities of arterial microcirculation in comparison with never-treated patients. |
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Authors:
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John Palios; Ignatios Ikonomidis; John Lekakis; Sotirios Tsiodras; Garyfalia Poulakou; Anastasia Antoniadou; Periklis Panagopoulos; Antonios Papadopoulos; Helen Giamarellou; Maria Anastasiou-Nana; Dimitrios Kremastinos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Microcirculation (New York, N.Y. : 1994) Volume: 17 ISSN: 1549-8719 ISO Abbreviation: Microcirculation Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-11 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9434935 Medline TA: Microcirculation Country: United States |
Other Details:
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Languages: eng Pagination: 303-10 Citation Subset: IM |
Affiliation:
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Second Department of Cardiology, Attikon University Hospital, University of Athens Medical School, Athens, Greece. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antiretroviral Therapy, Highly Active / adverse effects* Blood Flow Velocity / drug effects Case-Control Studies Forearm HIV Infections / complications, drug therapy*, physiopathology* HIV-1* Humans Hyperemia / physiopathology Hyperlipidemias / etiology, physiopathology Male Microcirculation / drug effects*, physiology Middle Aged Plethysmography |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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