Document Detail


Microcirculation: target therapy in cardiovascular diseases - a clinical perspective.
MedLine Citation:
PMID:  14724337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microcirculation conduit, distribution, exchange and reception vessels usually retain a demand-dependent vascular-tissue match as well as a nutrient friendly capillary-matrix tissue match. Various stimuli can initiate a vascular-capillary matrix-tissue mismatch. Counter-regulatory mechanisms result in hyperplasia or apoptosis. Microvascular disease (MVD) as a consequence or outcome of supply-demand mismatch has clinical therapeutic and prognostic implications in the hypertensive syndrome and coronary artery disease (CAD) cases. Recognition of the role of apoptosis and MVD may initiate a paradigm shift in clinical practice. Digitalis and other anti-hypertensive agents have anti-apoptotic action and MVD blunting effects that can control LVH development to reduce congestive heart failure (CHF) progression.
Authors:
Ramon F Abarquez; Jude Erric L Cinco
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  29     ISSN:  1386-0291     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  2003  
Date Detail:
Created Date:  2004-01-15     Completed Date:  2004-05-19     Revised Date:  2006-04-13    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  157-65     Citation Subset:  IM    
Affiliation:
Department of Medicine, Philippine General Hospital-College of Medicine, University of the Philippines, Manila, Philippines. cvlab@cm.upm.edu.ph
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Cardiovascular Diseases / complications,  drug therapy,  physiopathology*,  surgery
Coronary Artery Bypass
Coronary Circulation* / drug effects
Drug Design
Endothelium, Vascular / physiopathology
Gene Expression Regulation
Humans
Hypertrophy, Left Ventricular / etiology,  prevention & control
MAP Kinase Signaling System
Metabolic Syndrome X / complications
Mice
Microcirculation / drug effects
Vascular Resistance
Ventricular Remodeling

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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