Document Detail

Microcirculation of the pancreas. A quantitative study of physiology and changes in pancreatitis.
MedLine Citation:
PMID:  2323899     Owner:  NLM     Status:  MEDLINE    
A rabbit model was designed to study the microcirculation of the pancreas with special reference to changes occurring during acute pancreatitis. Intravital microscopy was used in conjunction with video techniques allowing for continuous observation and off-line evaluation of microvessel diameters and blood cell velocities. Based on the microvessel geometry a functional microvascular unit could be defined at the level of the pancreatic lobule consisting of intralobular arteries and veins and an arcade-like preferential pathway framing the capillary network. Experimental acute pancreatitis resulted in immediate leakage of the macromolecular plasma marker (FITC-Dextran 70) from the microvasculature suggesting increased permeability. In contrast to control conditions, pancreatic capillaries were excluded from the circulation during acute pancreatitis starting 30 min after induction with only single capillaries remaining perfused after 3 hours. At the same time, there was constant blood flow through the preferential pathways representing shunt perfusion.
E Klar; B Endrich; K Messmer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation     Volume:  9     ISSN:  0167-6865     ISO Abbreviation:  Int J Microcirc Clin Exp     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-05-16     Completed Date:  1990-05-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8400122     Medline TA:  Int J Microcirc Clin Exp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  85-101     Citation Subset:  IM    
Department of General Surgery, University of Heidelberg, FRG.
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MeSH Terms
Acute Disease
Capillaries / pathology,  physiopathology
Monitoring, Physiologic
Pancreas / blood supply*
Pancreatitis / pathology,  physiopathology*
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