Document Detail


Microcirculation of intestinal lymphoid follicles in rat Peyer's patches.
MedLine Citation:
PMID:  6972887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peyer's patch microvasculature carries recirculating lymphoid cells into lymphoid follicles and supports vigorous metabolic demands of crypts and replicating germinal centers. Scanning electron microscopy of methyl methacrylate casts of blood vessels in rat intestinal Peyer's patches revealed that ascending arterioles pierce follicles and feed to a subepithelial capillary network beneath the follicle surface. These capillaries interconnect with baskets of capillaries beneath adjacent crypts and flow into postcapillary venules in thymus-dependent areas around the follicle perimeters. This pattern is a modification of the fountain pattern in villi and reflects the secondary development of germinal centers of B lymphocytes between central ascending arterioles and peripheral postcapillary venules. Sections of glycol methacrylate-embedded follicles injected with India ink revealed multiple fine capillaries in germinal centers not detected by previous techniques. Capillary flow from follicle apex to adjacent crypts provides a route for feedback control of replenishment of the specialized antigen-trapping epithelium covering follicles, and it is an opportunity for absorbed materials and cellular products beneath the epithelium to modify migration of lymphocytes out of postcapillary venules into follicles.
Authors:
D K Bhalla; T Murakami; R L Owen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  81     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1981-09-25     Completed Date:  1981-09-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  481-91     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterioles / anatomy & histology
B-Lymphocytes
Capillaries / anatomy & histology
Lymphoid Tissue / blood supply*
Male
Microcirculation / anatomy & histology
Microscopy, Electron, Scanning
Peyer's Patches / blood supply*
Rats
Venules / anatomy & histology
Grant Support
ID/Acronym/Agency:
AM 21969/AM/NIADDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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