Document Detail


Microchip-based electrochemical detection for monitoring cellular systems.
MedLine Citation:
PMID:  23340999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of microchip devices to study cellular systems is a rapidly growing research area. There are numerous advantages of using on-chip integrated electrodes to monitor various cellular processes. The purpose of this review is to give examples of advancements in microchip-based cellular analysis, specifically where electrochemistry is used for the detection scheme. These examples include on-chip detection of single-cell quantal exocytosis, electrochemical analysis of intracellular contents, the ability to integrate cell culture/immobilization with electrochemistry, and the use of integrated electrodes to ensure cell confluency in longer-term cell culture experiments. A perspective on future trends in this area is also given.
Authors:
Alicia S Johnson; Asmira Selimovic; R Scott Martin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-01-23
Journal Detail:
Title:  Analytical and bioanalytical chemistry     Volume:  405     ISSN:  1618-2650     ISO Abbreviation:  Anal Bioanal Chem     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-15     Completed Date:  2013-08-28     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  101134327     Medline TA:  Anal Bioanal Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  3013-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells / chemistry*
Electrochemical Techniques / instrumentation,  methods*
Humans
Microchip Analytical Procedures / instrumentation,  methods*
Grant Support
ID/Acronym/Agency:
R15 GM084470/GM/NIGMS NIH HHS; R15GM084470-03/GM/NIGMS NIH HHS
Comments/Corrections

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