Document Detail

Microchip-associated sarcoma in a shrew (Suncus murinus).
MedLine Citation:
PMID:  20858367     Owner:  NLM     Status:  MEDLINE    
A 16-mo-old female house musk shrew (Suncus murinus) with a 1-wk history of a rapidly growing subcutaneous mass in the interscapsular region was euthanized and submitted for necropsy. Macroscopic examination identified an irregular, well-demarcated, solid, tan-white subcutaneous mass. A small cavity containing a microchip device was present at the center of the mass. In addition, massive splenomegaly was evident grossly. Histologically, the subcutaneous mass comprised spindle cells arranged in a storiform pattern of interweaving bundles, consistent with a high-grade soft tissue sarcoma with multifocal necrosis. Immunohistochemical investigation suggested that the neoplastic cells were positive for neuron-specific enolase and (rarely) α-smooth muscle actin and negative for cytokeratin, desmin, S100, and vimentin. In light of the mesenchymal histopathologic phenotype and the lack of specific immunoreactivity pattern, the mass was considered to be most consistent with a poorly differentiated sarcoma. To our knowledge, this is the first report of a microchip-associated soft tissue sarcoma in a shrew.
Leah K Schutt; Patricia V Turner
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the American Association for Laboratory Animal Science : JAALAS     Volume:  49     ISSN:  1559-6109     ISO Abbreviation:  J. Am. Assoc. Lab. Anim. Sci.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-22     Completed Date:  2011-06-08     Revised Date:  2011-07-25    
Medline Journal Info:
Nlm Unique ID:  101269489     Medline TA:  J Am Assoc Lab Anim Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  638-41     Citation Subset:  IM    
Department of Pathobiology, University of Guelph, Guelph, Canada.
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MeSH Terms
Actins / analysis
Animal Diseases / pathology
Animal Identification Systems / instrumentation*,  veterinary*
Animals, Laboratory
Intermediate Filament Proteins / analysis
Muscle, Smooth / chemistry
Phosphopyruvate Hydratase / metabolism
S100 Proteins / analysis
Sarcoma / etiology,  pathology*
Semiconductors / adverse effects,  veterinary
Shrews / physiology*
Reg. No./Substance:
0/Actins; 0/Intermediate Filament Proteins; 0/S100 Proteins; EC Hydratase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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