Document Detail


Microchimerism in type 1 diabetes.
MedLine Citation:
PMID:  19323957     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The observation that maternal cells can transfer from mother to child during pregnancy and differentiate into many different tissues including islet beta cells is exciting and intriguing, and to date has generated more questions than answers: Could these genetically distinct maternal cells play a role in the initiation of autoimmune diabetes in the child? Why do some individuals appear to have higher levels of maternal cells than others? What can we learn about how human beta cells differentiate from maternal stem cells? In this article, we review published data on maternal microchimerism in type 1 diabetes (and other autoimmune diseases) and discuss the technical limitations involved in the study of these maternally inherited cells. By improving the methodologies available for analysis of maternal cells in humans we will increasingly be in a position to answer the questions laid out above and to fully understand the biological insights generated by this experiment of nature.
Authors:
Berendine vanZyl; Kathleen M Gillespie
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current diabetes reports     Volume:  9     ISSN:  1539-0829     ISO Abbreviation:  Curr. Diab. Rep.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-27     Completed Date:  2009-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101093791     Medline TA:  Curr Diab Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-9     Citation Subset:  IM    
Affiliation:
University of Bristol, Southmead Hospital, Bristol BS10 5NB, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Chimerism*
Diabetes Mellitus, Type 1 / genetics*,  pathology
Female
Humans
Inheritance Patterns / genetics
Insulin-Secreting Cells / pathology
Maternal-Fetal Exchange
Pregnancy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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