Document Detail


Microchimerism in autoimmune disease: more questions than answers?
MedLine Citation:
PMID:  12848954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies indicate cell traffic occurs between the fetus and mother during pregnancy and that low numbers of fetal cells commonly persist in the maternal circulation for years thereafter. Microchimerism refers to a small number of cells or DNA from one individual harbored in another individual. Autoimmune diseases are more common among women and often increase in incidence following reproductive years. Chronic graft vs. host disease is an iatrogenic form of chimerism with similarities to some autoimmune diseases for which the HLA relationship of donor and host are of central importance. When considered together, these observations led to the hypothesis that microchimerism and HLA relationships of host and non-host cells are involved in autoimmune disease. The hypothesis is applicable to men, children and women without pregnancies because there are other sources of microchimerism, including from a twin, the mother or a blood transfusion. Microchimerism has now been investigated in a number of different diseases with some results supporting a potential role in disease pathogenesis. However, fetal and maternal microchimerism are also found in organs affected by non-autoimmune conditions. Moreover, microchimerism is commonly detected in the peripheral blood of healthy individuals raising the intriguing question of whether these cells are simple remnants of pregnancy or whether they might also have beneficial effects for the host.
Authors:
Nathalie Lambert; J Lee Nelson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Autoimmunity reviews     Volume:  2     ISSN:  1568-9972     ISO Abbreviation:  Autoimmun Rev     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-07-09     Completed Date:  2003-10-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101128967     Medline TA:  Autoimmun Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  133-9     Citation Subset:  IM    
Affiliation:
Program in Human Immunogenetics, Immunogenetics D2-100, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, Seattle, WA 98109-1024, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoimmune Diseases / etiology,  immunology*
Chimera*
Female
Graft vs Host Disease / immunology
HLA Antigens / immunology
Humans
Liver Cirrhosis, Biliary / immunology
Male
Maternal-Fetal Exchange / immunology
Models, Immunological
Pregnancy
Scleroderma, Systemic / immunology
Sjogren's Syndrome / immunology
Grant Support
ID/Acronym/Agency:
AI-41721/AI/NIAID NIH HHS; AI-45659/AI/NIAID NIH HHS; AR-48084/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/HLA Antigens

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